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Published TCIMAIL newest issue No.198
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CAS RN: 483-14-7 | Product Number: T3311
L-Tetrahydropalmatine
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Purity: >98.0%(HPLC)
Synonyms:
- (13aS)-2,3,9,10-Tetramethoxy-5,8,13,13a-tetrahydro-6H-dibenzo[a,g]quinolizine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 250MG |
€54.00
|
2 | 9 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T3311 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__5NO__4 = 355.43 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 483-14-7 |
| Reaxys Registry Number | 96288 |
| PubChem Substance ID | 253661327 |
| MDL Number | MFCD03265591 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 96.0 % |
| Melting point | 140.0 to 144.0 °C |
| Specific rotation [a]20/D | -278.0 to -298.0 deg(C=1, EtOH) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 142 °C |
| Specific Rotation | -283° (C=1,EtOH) |
| Maximum Absorption Wavelength | 280 nm |
GHS
Related Laws:
| RTECS# | HQ1792500 |
Transport Information:
| HS Number | 2933998090 |
Application
A Plant Alkaloid Effective in Multidrug Resistant Cancer Cells
L-Tetrahydropalmatine (L-THP or l-THP), the active enantiomer of THP [T3650], is an alkaloid found in several plant species such as Corydalis and Stephania. Corydalis Tuber (Corydalis yanhusuo) containing L-THP has been used for traditional Chinese pain medicine. Since L-THP antagonizes dopamine D1/D2 receptors and acts on dopamine D3 receptors, as well as α-adrenergic and serotonin receptors, it may have utility for treating opioid addiction.1,2) Furthermore, it has been reported that L-THP shows activity against antineoplastic resistant cancer cells.3) (The product is for research purpose only.)
References
- (－)-Tetrahydropalmatine and its analogues as new dopamine receptor antagonists
- l-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction (a review)
- The two enantiomers of tetrahydropalmatine are inhibitors of P-gp, but not inhibitors of MRP1 or BCRP
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