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CAS RN: 796-42-9 | Product Number: A3339
AS-8351
 
									 
							Purity: >98.0%(T)(HPLC)
Synonyms:
						
						- N'-[(2-Hydroxynaphthalen-1-yl)methylene]isonicotinohydrazide
- N'-[(2-Hydroxy-1-naphthyl)methylene]isonicotinohydrazide
Product Documents:
                    
				
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| Product Number | A3339 | 
| Purity / Analysis Method   | >98.0%(T)(HPLC) | 
| Molecular Formula / Molecular Weight | C__1__7H__1__3N__3O__2 = 291.31 | 
| Physical State (20 deg.C) | Solid | 
| Storage Temperature   | Refrigerated (0-10°C) | 
| Store Under Inert Gas | Store under inert gas | 
| Condition to Avoid | Hygroscopic,Heat Sensitive | 
| CAS RN | 796-42-9 | 
| Reaxys Registry Number | 267907 | 
| PubChem Substance ID | 468590241 | 
| MDL Number | MFCD00033110 | 
Specifications
		  | Appearance | White to Orange to Green powder to crystaline | 
| Purity(HPLC) | min. 98.0 area% | 
| Purity(Nonaqueous Titration) | min. 98.0 % | 
| NMR | confirm to structure | 
		Properties (reference)
	| Melting Point | 266 °C | 
| Maximum Absorption Wavelength | 367 nm (MeOH) | 
 
						 GHS
						  
								 Related Laws: 
							    
						Transport Information:
							| H.S.code* | 2933.39-000 | 
			Application
		
			AS-8351: An Iron Chelator Inhibiting the Activity of Histone Demethylase
		
		AS-8351 is reported to be an iron chelator with anti-tumor activity,1,2) and a histone demethylase inhibitor targeting KDM5B (JARID1B).3) (The product is for research purpose only.)
References
- 1) The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: the mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone
- 2) The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents III: the effect of the ligands on molecular targets involved in proliferation
- 3) Conversion of human fibroblasts into functional cardiomyocytes by small molecules
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