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CAS RN: 20350-15-6 | Product Number: B3820
Brefeldin A
×
Purity: >98.0%(HPLC)
Synonyms:
- γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic Acid λ-Lactone
- Ascotoxin
- Cyanein
- Decumbin
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
$132.00
|
0 | 0 | Contact Us | |
| 50MG |
$435.00
|
4 | 1 | Contact Us |
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | B3820 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__2__4O__4 = 280.36 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 20350-15-6 |
| Reaxys Registry Number | 25191 |
| PubChem Substance ID | 468590501 |
| Merck Index (14) | 1369 |
| MDL Number | MFCD12913297 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC)(CAD) | min. 98.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 204 °C |
| Specific Rotation | 93° (C=2,MeOH) |
| Maximum Absorption Wavelength | 215 nm (EtOH) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | GY8410000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2932.20-000 |
Application
Autophagy research / Mitophagy research
References
- Erythroleukemia cells acquire an alternative mitophagy capability
- Discovery of Atg5/Atg7-independent alternative macroautophagy
Application
CRISPR Genome Editing / Research on regenerative medicine
Brefeldin A enhances CRISPR-mediated homology-directed repair (HDR) efficiency.
Reference
- Small molecules enhance CRISPR genome editing in pluripotent stem cells
Application
Brefeldin A: A Macrolide Lactone Antibiotic used as an Inhibitor of Protein Trafficking and Secretion
Brefeldin A (BFA) is a natural fungal macrolide lactone antibiotic. Studies has demonstrated that BFA reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum. Therefore, BFA has been used as a tool to inhibit protein secretion and study the secretory pathway, effects of BFA on Golgi apparatus and other subcellular systems.
References
- Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum
- Brefeldin A: insights into the control of membrane traffic and organelle structure (a review)
- Brefeldin A: deciphering an enigmatic inhibitor of secretion (a review)
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