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CAS RN: 113558-15-9 | Product Number: B6443
Baohuoside I
 
									 
							Purity: >95.0%(T)(HPLC)
Synonyms:
						
						- Icariside II
- 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
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				| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time | Shipping Information   | 
|---|---|---|---|---|---|
| 25MG | 
                                                $291.00 | 17 | 0 | Contact Us | 
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| Product Number | B6443 | 
| Purity / Analysis Method   | >95.0%(T)(HPLC) | 
| Molecular Formula / Molecular Weight | C__2__7H__3__0O__1__0 = 514.53 | 
| Physical State (20 deg.C) | Solid | 
| Storage Temperature   | Refrigerated (0-10°C) | 
| Store Under Inert Gas | Store under inert gas | 
| Condition to Avoid | Air Sensitive,Heat Sensitive | 
| CAS RN | 113558-15-9 | 
| Reaxys Registry Number | 71248 | 
| MDL Number | MFCD15071140 | 
Specifications
		  | Appearance | White to Light yellow to Green powder to crystal | 
| Purity(HPLC) | min. 95.0 area% | 
| Purity(Neutralization titration) | min. 95.0 % | 
| Melting point | 202.0 to 206.0 °C | 
| Specific rotation | -127 to -137 deg(C=1, ethanol) | 
| NMR | confirm to structure | 
		Properties (reference)
	| Melting Point | 204 °C | 
 
						 GHS
						  
								 Related Laws: 
							   | RTECS# | DJ2980270 | 
 
						Transport Information:
							| H.S.code* | 2938.90-000 | 
			Application
		
			Baohuoside I: An Anticancer Metabolite of Icariin
		
		Herba Epimedii is one of most popular herbs used in China traditionally for the treatment of multiple diseases.  Baohuoside I (a synonym: Icariside II) is a hydrolysis metabolite of icariin [I0862] which is derived from Herba Epimedii.1,2)  There are reported that baohuoside I possess anticancer activities against various human cancer cell lines in vitro and mouse tumor models in vivo via their effects on multiple biological pathways including STAT3, PI3K/AKT, MAPK/ERK, COX-2/PGE2 and β-Catenin.3,4)  In addition, baohuoside I exerts its antimetastatic effect through the downregulation of CXCR4 (CXC chemokine receptor type 4) expression.5)  (The product is for research purpose only.)
References
- 1) LC-MS/MS method for the simultaneous determination of icariin and its major metabolites in rat plasma
- W. Xu, Y. Zhang, M. Yang, Z. Shen, X. Zhang, W. Zhang, H. Li, J. Pharm. Biomed. Anal. 2007, 45, 667. 
- 2) Preparation of icariside II from icariin by enzymatic hydrolysis method
- 3) Targeting apoptosis and multiple signaling pathways with icariside II in cancer cells
- 4) The Anticancer Properties of Herba Epimedii and Its Main Bioactive Componentsicariin and Icariside II (a review)
- 5) Baohuoside I Suppresses Invasion of Cervical and Breast Cancer Cells through the Downregulation of CXCR4 Chemokine Receptor Expression
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