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CAS RN: 149809-43-8 | Product Number: D4537
(3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl p-Toluenesulfonate
![Chemical Structure of (3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl p-Toluenesulfonate](/medias/D4537.jpg?context=bWFzdGVyfHJvb3R8NDUxMDJ8aW1hZ2UvanBlZ3xhR1ppTDJnM09DODRPVEl4TkRBNE1qQTRPVEkyTDBRME5UTTNMbXB3Wnd8NTFmODMzYzhlMjg1NWVjNWRjZGIyMTk4ZDE0ODg1MWI1ZTgwNmRlZDExY2I2ZTg5NDgxMTZhOWU3ZTI4MTg1NQ "(3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl p-Toluenesulfonate")
![Thumbnail of (3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl p-Toluenesulfonate](/medias/D4537.jpg?context=bWFzdGVyfHJvb3R8MTM4MDZ8aW1hZ2UvanBlZ3xhR1V4TDJneE9TODRPVE0wT0RJNU56ZzFNVEU0TDBRME5UTTNMbXB3Wnd8NTI2NmI0Yzg3N2MzNDc2NGE0OGY3MTU0ZDk4ZTQ4YmI4NzFiYTg2NTI2ZjM2NDNlZTVlMDZkNDI5ZGI3M2RkOA)
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![(3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl p-Toluenesulfonate](/_ui/responsive/theme-tci/images/missing_product_zoom.webp "(3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl p-Toluenesulfonate")
Purity: >98.0%(HPLC)
Synonyms:
- p-Toluenesulfonic Acid (3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl Ester
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
$54.00
|
10 | 6 | Contact Us |
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| Product Number | D4537 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__1F__2N__3O__4S = 449.47 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 149809-43-8 |
| Reaxys Registry Number | 6945701 |
| PubChem Substance ID | 253661982 |
| MDL Number | MFCD13195567 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 8.70 to 9.70 % |
| Melting point | 105.0 to 109.0 °C |
| Specific rotation [a]20/D | -41.0 to -44.0 deg(C=1, CHCl3) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 107 °C |
| Specific Rotation | -42° (C=1,CHCl3) |
| Solubility (slightly sol. in) | Chloroform |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2933.99-000 |
Application
A Synthetic Intermediate of Triazole Antifungals
This product has been used as a synthetic intermediate of triazole antifungals, such as posaconazole (Sch 56592) [P2477].
References
- Concise asymmetric routes to 2,2,4-trisubstituted tetrahydrofurans via chiral titanium imide enolates: key intermediates towards synthesis of highly active azole antifungals Sch 51048 and Sch 56592
- Enzymic Desymmetrization of Prochiral 2-Substituted-1,3-propanediols: A Practical Chemoenzymic Synthesis of a Key Precursor of SCH 51048, a Broad-Spectrum Orally Active Antifungal Agent
- Validated gradient stability indicating UPLC method for the determination of related substances of posaconazole posaconazole in bulk drug
Application
A Precursor for the Synthesis of Antifungal Agents
This compounds is a precursor for the synthesis of antifungal agents such as posaconazole (SCH 56592) and SCH 51048
References
- Concise asymmetric routes to 2,2,4-trisubstituted tetrahydrofurans via chiral titanium imide enolates: key intermediates towards synthesis of highly active azole antifungals SCH 51048 and SCH 56592
- Highly stereoselective access to novel 2,2,4-trisubstituted tetrahydrofurans by halocyclization: practical chemoenzymic synthesis of SCH 51048, a broad-spectrum orally active antifungal agent
- Enzymic Desymmetrization of Prochiral 2-Substituted-1,3-propanediols: A Practical Chemoenzymic Synthesis of a Key Precursor of SCH 51048, a Broad-Spectrum Orally Active Antifungal Agent
- Enantioselective synthesis of the optical isomers of broad-spectrum orally active antifungal azoles, SCH 42538 and SCH 45012
PubMed Literature
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