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CAS RN: 162359-56-0 | Product Number: F1018
Fingolimod Hydrochloride
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-Amino-2-[2-(4-n-octylphenyl)ethyl]propane-1,3-diol Hydrochloride
- FTY 720
- 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Hydrochloride
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
$117.00
|
20 | 10 | It can be shipped in about 2 weeks after ordering | |
| 1G |
$396.00
|
0 | 23 | It can be shipped in about 3-4 weeks after ordering |
* Please contact our distributors or
TCI
to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | F1018 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__3__3NO__2·HCl = 343.94 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 162359-56-0 |
| Related CAS RN
|
162359-55-9 |
| Reaxys Registry Number | 7837310 |
| PubChem Substance ID | 253660828 |
| Merck Index (14) | 4083 |
| MDL Number | MFCD00939512 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 110 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | TY3130000 |
Transport Information:
| H.S.code* | 2922.19-000 |
Application
Fingolimod hydrochloride (FTY720): An Immunomodulatory Agent Working as a Sphingosine 1-Phosphate Receptor Agonist
Fingolimod was first synthesized in 1992 by chemical modification of an immunosuppressive natural product, myriocin which is a metabolite of the fungus. Fingolimod hydrochloride (FTY720) is an orally active immunomodulatory agent, and inhibits lymphocyte emigration from lymphoid organs. Recent data show that FTY720 is a prodrug, and phosphorylated FTY720 is an agonist at sphingosine 1-phosphate (S1P) receptors. FTY720 is commonly used for the treatment of multiple sclerosis, an inflammatory disorder of the central nervous system. (The product is for research purpose only.)
References
- FTY720 Story. Its Discovery and the Following Accelerated Development of Sphingosine 1-Phosphate Receptor Agonists as Immunomodulators Based on Reverse Pharmacology (a review)
- Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
- The immune modulator FTY720 targets sphingosine 1-phosphate receptors
- FTY720: Sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function (a review)
- Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis (a review)
- FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation
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