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CAS RN: 160807-49-8 | Product Number: I1118
Indirubin-3'-monoxime
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Purity: >98.0%(HPLC)
Synonyms:
- 3-(Hydroxyimino)[2,3'-biindolinylidene]-2'-one
- 3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
- Indirubin-3'-oxime
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 50MG |
$300.00
|
0 | 31 | Contact Us |
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| Product Number | I1118 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__6H__1__1N__3O__2 = 277.28 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| CAS RN | 160807-49-8 |
| Reaxys Registry Number | 10094715 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Melting point | 239.0 to 243.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 241 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2933.79-000 |
Application
Indirubin-3'-monoxime: A Non-Specific Protein Kinase Inhibitor
Indirubin [I0868] is an active constituent of the traditional Chinese Medicine Danggui Longhui Wan which is used for years in the treatment of chronic myelocytic leukemia.1) Indirubin-3'-monoxime is a cell permeable derivative of indirubin, and a potent inhibitor of cyclin-dependent kinases (CDK) and glycogen synthase kinase-3β (GSK3β).1,2) There are reports that indirubin-3'-monoxime induce apoptosis and tumor cell death in transitional cell cancer cell lines.3) Indirubin-3'-monoxime also inhibits LRRK2 (leucine-rich repeat kinase 2) that is a promising therapeutic target for the treatment of Parkinson's disease.4,5) (The product is for research purpose only.)
References
- 1) Indirubin, the active constituent of a Chinese antileukemia medicine, inhibits cyclin-dependent kinases
- 2) GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins
- 3) Antiproliferative and apoptosis inducing effects of indirubin-3'-monoxime in renal cell cancer cells
- 4) Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
- 5) Development of LRRK2 Inhibitors for the Treatment of Parkinson’s Disease (a review)
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