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CAS RN: 34552-83-5 | Product Number: L0154
Loperamide Hydrochloride
×
Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
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| 5G |
$85.00
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10 | 2 | It can be shipped in about 2 weeks after ordering | |
| 25G |
$257.00
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| Product Number | L0154 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__9H__3__3ClN__2O__2·HCl = 513.50 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 34552-83-5 |
| Related CAS RN
|
53179-11-6 |
| Reaxys Registry Number | 4087090 |
| PubChem Substance ID | 87572105 |
| Merck Index (14) | 5571 |
| MDL Number | MFCD00058581 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Solubility in Methanol | almost transparency |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 223 °C |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Ethanol, dichloromethane |
| Solubility (insoluble in) | Ether |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | TM4960000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2933.39-000 |
Application
Loperamide Hydrochloride: An Opioid Receptor Agonist in the Gastrointestinal Tract
Loperamide hydrochloride, an opioid agonist, reduces gastrointestinal motility in animals and human through activation of opioid receptors in the gastrointestinal tract. It cannot readily cross the blood-brain barrier, and does not appear to exert opiate activity in human. Loperamide is used as an antidiarrheal agent. (The product is for research purpose only.)
References
- Loperamide: survey of studies on mechanism of its antidiarrheal activity (a review)
- Delivery of loperamide across the blood-brain barrier with Polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles
- Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity
- Loperamide and P-glycoprotein inhibition: assessment of the clinical relevance (a review)
- Loperamide hydrochloride
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