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CAS RN: 113-98-4 | Product Number: P1772
Penicillin G Potassium Salt
×
Purity: >98.0%(HPLC)(N)
Synonyms:
- Benzylpenicillin Potassium Salt
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
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|---|---|---|---|---|---|
| 25G |
$67.00
|
35 | ≥100 | Contact Us |
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Supplemental Product Information:
This product has not been tested for potency and is guaranteed for chemical purity.
| Product Number | P1772 |
Purity / Analysis Method 
|
>98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__6H__1__7KN__2O__4S = 372.48 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Hygroscopic |
| CAS RN | 113-98-4 |
| Related CAS RN
|
61-33-6 |
| Reaxys Registry Number | 3832841 |
| PubChem Substance ID | 87560525 |
| Merck Index (14) | 7094 |
| MDL Number | MFCD00036193 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Specific rotation [a]20/D | +270.0 to +300.0 deg(C=1, H2O) |
Properties (reference)
| Melting Point | 217 °C(dec.) |
| Specific Rotation | 294° (C=1,H2O) |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P261 : Avoid breathing dust. P272 : Contaminated work clothing should not be allowed out of the workplace. P280 : Wear protective gloves. P284 : Wear respiratory protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P362 + P364 : Take off contaminated clothing and wash it before reuse. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. P333 + P313 : If skin irritation or rash occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | XH9700000 |
Transport Information:
| H.S.code* | 2941.10-000 |
Application
Penicillin G: The First Antibiotic belongs to Penicillins
Penicillin is the first antibiotic isolated from the mold Penicillium noctum, specifically it is known as penicillin G (other name: benzylpenicillin) and belongs to a class of similar antibiotics called penicillins. Nowadays penicillin G is produced by Penicillium chrysogenum fermentation. Penicillin G has activity against Gram-positive bacteria, but less activity against Gram-negative bacteria. It acts as a competitive inhibitor of the enzyme transpeptidase, which is needed by bacteria to make their cell walls. Meanwhile, β-lactamases (also called penicillinases) are enzymes produced by bacteria that deactivate penicillin G by destroying the β-lactam ring via hydrolysis. In rare cases, an allergy to penicillin G can cause an anaphylactic reaction, which can be deadly. Currently, the enzymatic hydrolysis of penicillin G gives 6-aminopenicillanic acid (6-APA) [A0800], which is a basic raw material for the industrial production of semisynthetic β-lactamase-resistant and broad spectrum penicillins such as amoxycillin [A2099] and ampicillin [A2092].
References
- Penicillin: the medicine with the greatest impact on therapeutic outcomes (a review)
- Penicillin G, potassium (a review)
- Staphylococcal cell wall: morphogenesis and fatal variations in the presence of penicillin (a review)
- Diagnosis of immediate allergic reactions to beta-lactam antibiotics (a review)
- Advances in enzymatic transformation of penicillins to 6-aminopenicillanic acid (6-APA)
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