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Published TCIMAIL newest issue No.198
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CAS RN: 121268-17-5 | Product Number: A2456
Alendronate Sodium Trihydrate
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Purity: >97.0%(T)
Synonyms:
- Alendronic Acid Monosodium Salt Trihydrate
- (4-Amino-1-hydroxy-1-phosphonobutyl)phosphonic Acid Monosodium Salt Trihydrate
- Monosodium (4-Amino-1-hydroxy-1-phosphonobutyl)phosphonate Trihydrate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€53.00
|
1 | ≥100 |
|
| 25G |
€169.00
|
Contact Us | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A2456 |
| Purity / Analysis Method | >97.0%(T) |
| Molecular Formula / Molecular Weight | C__4H__1__2NNaO__7P__2·3H__2O = 325.13 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 121268-17-5 |
| Related CAS RN | 66376-36-1&129318-43-0 |
| Reaxys Registry Number | 6947932 |
| PubChem Substance ID | 135727181 |
| Merck Index (14) | 229 |
| MDL Number | MFCD01748233 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(Neutralization titration) | min. 97.0 % |
| Drying loss | 16.1 to 17.1 % |
Properties (reference)
| Solubility in water | Slightly soluble |
| Solubility (insoluble in) | Chloroform |
GHS
Related Laws:
| RTECS# | SZ6523666 |
Transport Information:
| HS Number | 2931498090 |
Application
Studies of Alendronate Biological Actions
References
- Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure
- Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro
- Synthesis, characterization and biodistribution of bisphosphonates Sm-153 complexes: correlation with molecular modeling interaction studies
- Synthesis and Study of Alendronate Derivatives as Potential Prodrugs of Alendronate Sodium for the Treatment of Low Bone Density and Osteoporosis
Application
Bone Resorption Inhibitors
References
- 1)Anti-bone resorption
- a)J. E. Dunford, K. Thompson, F. P. Coxon, S. P. Luckman, F. M. Hahn, C. D. Poulter, F. H. Ebetino, M. J. Rogers., J. Pharmacol. Exp. Ther. 2001, 296, 235.
- b)E. Hiroi-Furuya, T. Kameda, K. Hiura, H. Mano, K. Miyazawa, Y. Nakamaru, M. Watanabe-Mano, N. Okuda, J. Shimada, Y. Yamamoto, Y. Hakeda, M. Kumegawa, Calcif. Tissue Int. 1999, 64, 219.
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