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CAS RN: 6055-19-2 | Product Number: C2236

Cyclophosphamide Monohydrate


Purity: >98.0%(N)
Synonyms:
  • 2-[Bis(2-chloroethyl)amino]tetrahydro-1,3,2-oxazaphosphorin-2-oxide Monohydrate
Documents:
5G
€78.00
4   ≥20 
25G
€315.00
3   ≥20 

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*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).


Product Number C2236
Purity / Analysis Method >98.0%(N)
Molecular Formula / Molecular Weight C__7H__1__5Cl__2N__2O__2P·H__2O = 279.1  
Physical State (20 deg.C) Solid
Storage Temperature 0-10°C
Store Under Inert Gas Store under inert gas
Condition to Avoid Light Sensitive,Air Sensitive,Heat Sensitive
CAS RN 6055-19-2
Related CAS RN 50-18-0
Reaxys Registry Number 8167897
PubChem Substance ID 125307342
Merck Index (14) 2747
MDL Number

MFCD00149395

Specifications
Appearance White to Almost white powder to crystal
Purity(with Total Nitrogen) min. 98.0 %(calcd.on anh.substance)
Melting point 49.0 to 53.0 °C
Water max. 8.0 %
Properties (reference)
Melting Point 51 °C
Solubility in water Slightly soluble
Solubility (very soluble in) Ethanol,Chloroform
Solubility (soluble in) Ether
GHS
Pictogram Pictogram Pictogram
Signal Word Danger
Hazard Statements H301 : Toxic if swallowed.
H315 : Causes skin irritation.
H362 : May cause harm to breast-fed children.
H340 : May cause genetic defects.
H350 : May cause cancer.
Precautionary Statements P263 : Avoid contact during pregnancy and while nursing.
P260 : Do not breathe dust or mist.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth.
Related Laws: / Compliance with laws, Regulations
Enzyme Commission 200-015-4
RTECS# RP6157750
Transport Information:
UN Number UN3464
Class 6.1
Packing Group III
HS Number 2934999090
Application
Reagent for cystitis model
References

Uroprotective effect of pentoxifylline in cyclophosphamide-induced hemorrhagic cystitis in rats

O. M. Abo-Salem, J. Biochem Mol. Toxicol. 2013, 27, 343.

Relevance of the cyclophosphamide-induced cystitis model for pharmacological studies targeting inflammation and pain of the bladder

C. Augé, G. Chene, M. Dubourdeau, D. Desoubzdanne, B. Corman, S. Palea, P. Lluel, N. Vergnolle, A. M. Coelho, Eur. J. Pharmacol. 2013, 707, 32.

Effect of intrathecal administration of E-series prostaglandin 1 receptor antagonist in a cyclophosphamide-induced cystitis rat model

N, Wada, S. Matsumoto, M. Kita, M. Watanabe, K. Hashizume, H. Kakizaki, Int. J. Urol. 2013, 20, 235.

Effect of silymarin on bladder overactivity in cyclophosphamide-induced cystitis rat model

N. Eser, C. Göçmen, S. Erdoğan, H. S. Büyüknacar, E. K. Kumcu, A. Açıkalın, S. Önder, Phytomedicine 2012, 19, 840.


Application
Reagent for hematopoietic disorder model
References

A rabbit used as a model for testing hematopoietic tissue transplants

S. Kosiński, H. Matej, Arch. Immunol. Ther. Exp. (Warsz) 1978, 26, 1021.

Immunomodulatory effects of moxifloxacin in comparison to ciprofloxacin and G-CSF in a murine model of cyclophosphamide-induced leukopenia

I Shalit, Y. Kletter, D. Halperin, D. Waldman, E. Vasserman, A. Nagler, I. Fabian, Eur. J. Haematol. 2001, 66, 287.


Application
Reagent for overactive bladder model
References

Cyclophosphamide cystitis--identification of acrolein as the causative agent

P. J. Cox, Biochem Pharmacol. 1979, 28, 2045.

Cyclophosphamide cystitis in rats: involvement of capsaicin-sensitive primary afferents

C. A. Maggi, A. Lecci, P. Santicioli, E. Del Bianco, S. Giuliani, J. Auton. Nerv. Syst. 1992, 38, 201.

Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation

N. Yoshimura, W. C. de Groat, J. Neurosci. 1999, 19, 4644.

Cyclophosphamide cystitis in mice: behavioural characterisation and correlation with bladder inflammation

T. Olivar, J. M. Laird, Eur. J. Pain. 1999, 3, 141.

Cyclophosphamide-induced cystitis in freely-moving conscious rats: behavioral approach to a new model of visceral pain

M. Boucher, M. Meen, J. P. Codron, F. Coudore, J. L. Kemeny, A. Eschalier, J. Urol. 2000, 164, 203.

Comparison of voiding function and nociceptive behavior in two rat models of cystitis induced by cyclophosphamide or acetone

C. Saitoh, H. Yokoyama, M. B. Chancellor, W. C. de Groat, N. Yoshimura, Neurourol. Urodyn. 2010, 29, 501.


Application
Reagent for nausea or vomiting model
References

The antiemetic effect of a novel tropisetron patch in anticancer agents-induced kaolin pica model using rats

S. W. Jeong, J. W. Cho, J. S. Hwang, J. D. Song, S. Shin, J. Y. Jang, S. Y. Hwang, O. Kim, J. C. Kim, Y. B. Kim, J. K. Kang, Environ. Toxicol. Pharmacol. 2005, 20, 167.

The anti-cancer drug-induced pica in rats is related to their clinical emetogenic potential

K. Yamamoto, M. Nakai, K. Nohara, A. Yamatodani, Eur. J. Pharmacol. 2007, 554, 34.


Application
Reviews on the Pharmacology of Cyclophosphamide
References

An overview of cyclophosphamide and ifosfamide pharmacology

R. A. Fleming, Pharmacotherapy 1997, 17, 146S.

Cyclophosphamide: Review of its mutagenicity for an assessment of potential germ cell risks

D. Anderson, J. B. Bishop, R. C. Garner, P. Ostrosky-Wegman, P. B. Selby, Mutat. Res. 1995, 330, 115.

The chemistry of the metabolites of cyclophosphamide

S. M. Ludeman, Curr. Pharm. Des. 1999, 5, 627.

Mechanisms of resistance to the toxicity of cyclophosphamide

M. P. Gamcsik, M. E. Dolan, B. S. Andersson, D. Murray, Curr. Pharm. Des. 1999, 5, 587.


Application
Preparation
References

H. Arnold, F. Bourseaux, Angew. Chem. 1958, 70, 539.


Application
Optical resolution study
References

Optical resolution studies of cyclophosphamide

T. Kawashima, R. D. Kroshefsky, R. A. Kok, J. G. Verkade, J. Org. Chem. 1978, 43, 1111.


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