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Published TCIMAIL newest issue No.198
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CAS RN: 1070-11-7 | Product Number: E1011
Ethambutol Dihydrochloride
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Purity: >98.0%(T)
Synonyms:
- (S,S)-N,N'-Bis(1-hydroxy-2-butyl)ethylenediamine Dihydrochloride
- (S,S)-2,2'-(1,2-Ethanediyldiimino)bis-1-butanol Dihydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€26.00
|
2 | 21 |
|
| 25G |
€92.00
|
2 | 35 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | E1011 |
Purity / Analysis Method 
|
>98.0%(T) |
| Molecular Formula / Molecular Weight | C__1__0H__2__4N__2O__2·2HCl = 277.23 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 1070-11-7 |
| Related CAS RN
|
74-55-5 |
| PubChem Substance ID | 253662167 |
| Merck Index (14) | 3720 |
| MDL Number | MFCD00216025 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Purity(Argentometric Titration) | min. 98.0 % |
| Melting point | 199.0 to 204.0 °C |
| Specific rotation [a]20/D | +5.0 to +7.0 deg(C=10, H2O) |
Properties (reference)
| Melting Point | 199 °C |
| Specific Rotation | 6° (C=10,H2O) |
| Solubility (slightly sol. in) | Ethanol |
| Solubility (insoluble in) | Ether |
GHS
Related Laws:
| EC Number | 213-970-7 |
| RTECS# | EL3854000 |
Transport Information:
| HS Number | 2922190090 |
Application
EMB: A bacteriostatic Antituberculous Agent
(S,S)-N,N'-Bis(1-hydroxy-2-butyl)ethylenediamine dihydrochloride (commonly abbreviated EMB), a chemical synthetic bacteriostatic antituberculous agent, is a strong inhibitor of the mycobacterial cell wall biosynthesis. EMB is usually given in combination with other antituberculous agents, such as isoniazid [I0138], rifampicin [R0079] and pyrazinamide [P0633].
References
- The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol
- The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol
- Biogenesis of the mycobacterial cell wall and the site of action of ethambutol
- Anti-Tuberculosis Drugs
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