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Published TCIMAIL newest issue No.199
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CAS RN: 62996-74-1 | Product Number: T4000
Staurosporine
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Purity: >98.0%(HPLC)
Synonyms:
- (5S,6R,7R,9S)-6-Methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14-one
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
€157.00
|
12 | ≥100 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | T4000 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__8H__2__6N__4O__3 = 466.54 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 62996-74-1 |
| Reaxys Registry Number | 6674025 |
| PubChem Substance ID | 468593064 |
| MDL Number | MFCD18252446 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation | +71.0 to +75.0 deg(C=0.1, ﾒﾀﾉｰﾙ) |
| NMR | confirm to structure |
Properties (reference)
GHS
| Hazard Statements | H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
Related Laws:
| RTECS# | KC6550000 |
Transport Information:
| HS Number | 2941900000 |
Application
Staurosporine: A Potent Inhibitor of Protein Kinase
Staurosporine (AM-2282) is an indolocarbazole antibiotic originally isolated from the bacterium Streptomyces staurosporeus by Omura et al. in 1977.1) It has been reported that staurosporine and display strong inhibitory effect against a variety of kinases including protein kinase C (PKC), and a number of biological properties such as antifungal, antibacterial, and apoptosis-inducing activities1,2). Staurosporine also inhibits wild-type LRRK2 (leucine-rich repeat kinase 2), which is a large protein (2527 amino acids) with serine-threonine (Ser/Thr) protein kinase activity and autophosphorylation activity.3) Nevertheless, staurosporine is poorly selective against other protein kinases. To obtain specific PKC inhibitors, a number of its analogues has been developed.4,5) (The product is for research purpose only.)
References
- 1) Staurosporine, a Potentially Important Gift from a Microorganism (a review)
- 2) Induction of a common pathway of apoptosis by staurosporine
- 3) Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2
- 4) Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine (a review)
- 5) Protein kinase inhibition of clinically important staurosporine analogues (a review)
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