Gilman reaction is a name reaction as typified by 1,4-additions of α,β-unsaturated ketones as well as SN2-type alkylation of alkyl halides. Gilman reagents are organocopper compounds typically illustrated by C-Cu-C core with a lithium counterion and are particularly useful for the Gilman reaction. The reagents are readily preparable from 2 equiv. of alkyllithium reagents and a copper(I) salt such as CuI.
Reagents: Gilman reagents
Reactants: α,β-unsaturated carbonyl compounds, alkyl halides
Products: corresponding adducts
- The Preparation of Methylcopper and some Observations on the Decomposition of Organocopper Compounds
- Henry Gilman: American Pioneer in the Rise of Organometallic Chemistry in Modern Science and Technology