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Nitric Oxide Donor Activated by Two-Photon Excitation

No.156(January 2013)
D3959
Flu-DNB Monohydrate (1)
Flu-DNB (1), which was developed by Nakagawa et al., is a nitric oxide (NO) donor activated by two-photon excitation (TPE). 1 has the fluorescein structure as a two-photon absorbing moiety and the 2,6-dimethylnitrobenzene structure as an NO release moiety, which is activated by two-photon excitation upon 720 nm pulse laser irradiation to release NO. Since 1 does not contain any transition metal complexes and biocompatible long-wavelength lights can be applied, 1 would be highly advantageous for biological applications.

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