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Published TCIMAIL newest issue No.199
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CAS RN: 133073-73-1 | Product Number: M1664
Methotrexate Hydrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (+)-Amethopterin Hydrate
Product Documents:
| Size | Unit Price | Belgium | Japan* |
|---|---|---|---|
| 1G |
€92.00
|
3 | ≥100 |
| 5G |
€357.00
|
3 | 18 |
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M1664 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__2__2N__8O__5·xH__2O = 454.45 (as Anhydrous) |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Hygroscopic |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 133073-73-1 |
| Related CAS RN
|
59-05-2 |
| Reaxys Registry Number | 70669 |
| PubChem Substance ID | 87558856 |
| Merck Index (14) | 5985 |
| MDL Number | MFCD00150847 |
Specifications
| Appearance | Light yellow to Brown powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 %(calcd.on anh.substance) |
| Specific rotation [a]20/D | +18.0 to +23.0 deg(C=0.1, 1mol/L NaOH sol.)(calcd.on anh.substance) |
| Water | max. 10.0 % |
Properties (reference)
| Melting Point | 205 °C(dec.) |
| Specific Rotation | 21° (C=0.1,1mol/L NaOH sol.) |
| Solubility in water | Insoluble |
| Solubility (insoluble in) | Ether, Chloroform, Alcohol |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. H360 : May damage fertility or the unborn child. H372 : Causes damage to organs through prolonged or repeated exposure. |
| Precautionary Statements | P260 : Do not breathe dust. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 200-413-8 |
| RTECS# | MA1225000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2933998090 |
Application
Quorum sensing inhibitor
Reference
- The Role of Drug Repurposing in the Development of Novel Antimicrobial Drugs: Non-Antibiotic Pharmacological Agents as Quorum Sensing-Inhibitors
Application
Methotrexate: An Inhibitor of Dihydrofolate Reductase (DHFR)
Methotrexate (MTX), analog of folic acid, is an inhibitor of the enzyme dihydrofolate reductase (DHFR) which catalyzes the conversion of dihydrofolate to the active tetrahydrofolate, leading to interfere with folic acid metabolism. Result is inhibition of DNA synthesis and cell proliferation in S phases (the phase of DNA synthesis). Also, MTX has immunosuppressive and anti-inflammatory activity. Although no single mechanism is sufficient to account for all the anti-inflammatory activities of methotrexate, the release of adenosine from cells has been demonstrated. MTX is commonly used for the treatment of certain cancers including leukemia, rheumatoid arthritis, Crohn’s disease and psoriasis. (The product is for research purpose only.)
References
- Mechanisms of action of methotrexate
- Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis
- Molecular therapeutics: Methotrexate and its mechanism of action
- Intrinsic and acquired resistance to methotrexate in acute leukemia
- Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis
- Methotrexate-how does it really work? (a review)
- Determination of methotrexate in human serum by high-performance liquid chromatography combined with pseudo template molecularly imprinted polymer
PubMed Literature
Documents
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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