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CAS RN: 5794-13-8 | Product Number: A0542
L-Asparagine Monohydrate
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Purity: >99.0%(T)(HPLC)
Synonyms:
- H-Asn-OH Monohydrate
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| Product Number | A0542 |
Purity / Analysis Method 
|
>99.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__4H__8N__2O__3·H__2O = 150.14 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 5794-13-8 |
| Reaxys Registry Number | 1723527 |
| PubChem Substance ID | 87562142 |
| Merck Index (14) | 837 |
| MDL Number | MFCD00151038 |
Specifications
| Appearance | White powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Optical purity(LC) | min. 98.0 ee% |
| Purity(Nonaqueous Titration) | min. 99.0 % |
| Drying loss | 11.5 to 12.5 % |
Properties (reference)
| Melting Point | 235 °C |
| Specific Rotation | 31° (C=10,HCl(1+3)) |
| Solubility (insoluble in) | Ether, Ethanol |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2924.19-000 |
Application
Bacterial spore germinant research
Bacterial spores are more resistant to antibiotics and nutritional deficiencies than their vegetative cells and sometimes cause serious problems from the viewpoint of hygiene in clinical treatment and food processing.1) Spore persistence also plays a major role in the recurrence of infections after antibiotic treatment. Molecules that stimulate germination are termed “germinants”1) and the efficacy of germinant administration combined with antibiotics have been evaluated (for example, reports by N. Budi et al.2,3)). Cogerminants are compounds that do not have germination-stimulating activity in themselves but stimulate germination when combined with other compounds. L-Asparagine has been reported to act as a cogerminant for spores of Clostridium perfringens and Bacillus subtilis.4,5)
(The product is for research purpose only.)
(The product is for research purpose only.)
References
- 1) Germinants and Their Receptors in Clostridia
- 2) Omadacycline compared to vancomycin when combined with germinants to disrupt the life cycle of Clostridioides difficile.
- 3) Efficacy of Omadacycline or Vancomycin Combined With Germinants for Preventing Clostridioides difficile Relapse in a Murine Model
- 4) Role of GerKB in Germination and Outgrowth of Clostridium perfringens Spores
- 5) Initiation of the Germination of Bacillus subtilis Spores by a Combination of Compounds in Place of L-Alanine
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