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CAS RN: 129-56-6 | Product Number: A2548
Anthra[1,9-cd]pyrazol-6(2H)-one
![Thumbnail of Anthra[1,9-cd]pyrazol-6(2H)-one](/medias/A2548.jpg?context=bWFzdGVyfHJvb3R8MTc0OTd8aW1hZ2UvanBlZ3xhR1UzTDJnd09DODRPVE16TVRFeE56VTRPRGM0TDBFeU5UUTRMbXB3Wnd8OTNiMTI5ZDlkMjA1ZjYzNThlOTFhNDRmNDNmZGQyZDRkYzEwOGFjMGQyM2U0YTM3MzkxNDY3MmY0YTJhOTVmZg "Anthra[1,9-cd]pyrazol-6(2H)-one")
![Chemical Structure of Anthra[1,9-cd]pyrazol-6(2H)-one](/medias/A2548.jpg?context=bWFzdGVyfHJvb3R8NTg4ODB8aW1hZ2UvanBlZ3xhRGszTDJnelpTODRPVEU1TmpZNU56TTFORFUwTDBFeU5UUTRMbXB3Wnd8ZmEyZjgzY2U5OWM4ZTAyMjMwYzlkOTliYThlYThjMzdhNWVjZmM5YTM5MjBiZGYxOTJkMDU1NGVjOThiNWYzZQ "Anthra[1,9-cd]pyrazol-6(2H)-one")
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![Anthra[1,9-cd]pyrazol-6(2H)-one](/_ui/responsive/theme-tci/images/missing_product_zoom.webp "Anthra[1,9-cd]pyrazol-6(2H)-one")
Purity: >95.0%(HPLC)
Synonyms:
- Dibenzo[cd,g]indazol-6(2H)-one
- SP 600125
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
$178.00
|
0 | 34 | Contact Us |
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* The storage conditions are subject to change without notice.
| Product Number | A2548 |
Purity / Analysis Method 
|
>95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__4H__8N__2O = 220.23 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 129-56-6 |
| Reaxys Registry Number | 746890 |
| PubChem Substance ID | 253659651 |
| MDL Number | MFCD00022289 |
Specifications
| Appearance | Light yellow to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 282 °C |
GHS
Related Laws:
| RTECS# | CB4585000 |
Transport Information:
| H.S.code* | 2933.99-000 |
Application
LRRK2 Inhibitory Effect of SP600125
This product (SP600125) is an inhibitor of Jun N-terminal kinase (JNK), which is a stress-activated protein kinase that can be induced by inflammatory cytokines, bacterial endotoxin, osmotic shock, UV radiation, and hypoxia. In addition, there is a report that SP600125 inhibits LRRK2 (Leucine-rich repeat kinase 2) -G2019S, which is a promising therapeutic target for the treatment of Parkinson's disease, in the low micro-molar range. (The product is for research purpose only.)
References
- Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
- Small Molecule Kinase Inhibitors for LRRK2 and Their Application to Parkinson's Disease Models (a review)
Application
Apoptosis
References
- PEDF induces p53-mediated apoptosis through PPAR gamma signaling in human umbilical vein endothelial cells
- Nongenotropic, anti-apoptotic signaling of 1α,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes: MEDIATION BY Src, PHOSPHATIDYLINOSITOL 3-, AND JNK KINASES
Application
c-Jun N-Terminal Kinase (JNK) Inhibitor
References
- 1)SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
- 2)Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
- 3)A mammalian scaffold complex that selectively mediates MAP kinase activation
- 4)Scaffold proteins of MAP-kinase modules
- 5)Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1
PubMed Literature
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Other Documents
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SP 600125 [Optimized for Cell Culture]
| Product # | P3160 |
| CAS RN | 129-56-6 |
| Purity / Analysis Method: |