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CAS RN: 141396-28-3 | Product Number: A2705
Argatroban Monohydrate
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Purity: >99.0%(HPLC)
Synonyms:
Product Documents:
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| Product Number | A2705 |
Purity / Analysis Method 
|
>99.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__3__6N__6O__5S·H__2O = 526.66 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 141396-28-3 |
| Related CAS RN
|
74863-84-6 |
| PubChem Substance ID | 253661816 |
| Merck Index (14) | 779 |
| MDL Number | MFCD00895735 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Elemental analysis(Nitrogen) | 15.50 to 16.50 % |
| Specific rotation [a]20/D | +160.0 to +170.0 deg(C=0.8, MeOH)(calcd.on anh.substance) |
| Water | 2.5 to 4.5 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 180 °C(dec.) |
| Specific Rotation | 165° (C=0.8,MeOH) |
| Solubility in water | Insoluble |
| Solubility (slightly sol. in) | Methanol |
| Solubility (insoluble in) | Ether, Acetone |
GHS
Related Laws:
| RTECS# | TM6126625 |
Transport Information:
| H.S.code* | 2935.90-000 |
Application
Argatroban: A Direct Thrombin Inhibitor Act as an Anticoagulant
Argatroban is a synthetic selective thrombin inhibitor. It is known that argatroban exerts inhibiting activities on fibrin generation, platelet aggregation and vasoconstriction by direct interacting with thrombin. Due to these activities, argatoroban is utilized as an ingredient for anticoagulant and antithrombotic. Argatroban is also used as one of positive control drugs for thrombosis model animals. (This product is for research purpose only.)
References
- Comparative study on heparin and a synthetic thrombin inhibitor no. 805 (MD-805*) in experimental antithrombin III-deficient animals
- Potent inhibition of thrombin by the newly synthesized arginine derivative No. 805. The importance of stereo-structure of its hydrophobic carboxamide portion
- Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-arginyl]-2-piperidinecarboxylic acid
- Antithrombotic actions of argatroban in rat models of venous, 'mixed' and arterial thrombosis, and its effects on the tail transection bleeding time
- Effects of a thrombin inhibitor, argatroban, on ischemic brain damage in the rat distal middle cerebral artery occlusion model.
- Argatroban (a review)
- Direct thrombin inhibitors in acute coronary syndromes: present and future (a review)
- Argatroban: Update (a review)
PubMed Literature
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