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CAS RN: 989-51-5 | Product Number: E0694
(-)-Epigallocatechin Gallate Hydrate
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Purity: >98.0%(HPLC)
Synonyms:
- EGCG Hydrate
- (-)-cis-3,4-Dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-1(2H)-benzopyran-3-yl Gallate Hydrate
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
$80.00
|
21 | ≥100 | It can be shipped in about 1 week after ordering | |
| 500MG |
$278.00
|
8 | 0 | It can be shipped in about 2 weeks after ordering |
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TCI
to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | E0694 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__2H__1__8O__1__1·xH__2O = 458.38 (as Anhydrous) |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 500MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 989-51-5 |
| Related CAS RN
|
1257-08-5 |
| Reaxys Registry Number | 67944 |
| PubChem Substance ID | 87558853 |
| Merck Index (14) | 3526 |
| MDL Number | MFCD00075940 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Specific rotation [a]20/D | -165.0 to -186.0 deg(C=1, EtOH) |
| Water | max. 5.0 % |
Properties (reference)
| Melting Point | 212 °C |
| Specific Rotation | -176° (C=1,EtOH) |
| Solubility (soluble in) | Ethanol |
GHS
Related Laws:
| RTECS# | KB5200000 |
Transport Information:
| H.S.code* | 2932.99-000 |
Application
Research on gene transfer methods / Enhancement of lipofection efficiency
(-)-Epigallocatechin gallate has been reported to enhance the transfection efficiency in Colon26 and HepG2 cells.1)
Reference
- 1) Flavonoids Enhance Lipofection Efficiency and Ameliorate Cytotoxicity in Colon26 and HepG2 Cells via Oxidative Stress Regulation
- 1) Inhibitory effect of green tea catechins on cysteine proteinases in Porphyromonas gingivalis
- 2) Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenyl flavonoids
- 1) Epigallocatechin-Gallate Enhances the Activity of Tetracycline in Staphylococci by Inhibiting Its Efflux from Bacterial Cells
- Epigallocatechin gallate inhibits the type III secretion system of Gram-negative enteropathogenic bacteria under model conditions
- Epigallocatechin-3-gallate inhibits bacterial virulence and invasion of host cells
- Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions (a review)
- Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications (a review)
- Green tea and its anti-angiogenesis effects (a review)
- Absorption, metabolism, anti-cancer effect and molecular targets of epigallocatechin gallate (EGCG): An updated review
- Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases (a review)
Application
Gingipain inhibitor
Catechin derivatives, which included (-)-epigallocatechin gallate, (-)-epicatechin gallate, (-)-gallocatechin gallate, and (-)-catechin gallate, have been reported to inhibit Arg-gingipain (Rgp) in Porphyromonas gingivalis.1) The 50% inhibitory concentrations (IC50s) of these catechin derivatives for Rgp ranged from 3 to 5 μM. (-)-Epigallocatechin gallate is one of these derivatives. The compound was also shown to inhibit Lys-gingipain (Kgp), although weaker than Rgp.2)
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
Application
Efflux pump research
(-)-Epigallocatechin Gallate has been reported to inhibit efflux pump thereby enhancing the activity of tetracycline [T3971, T2525] in Staphylococci.1)
(The product is for research purpose only.)
(The product is for research purpose only.)
Reference
Application
Type III secretion system (T3SS) research / Type III secretion system (T3SS) inhibitor
References
Application
(-)-Epigallocatechin Gallate (EGCG): A Polyphenolic Compound with Diverse Biological Activities including Anti-Cancer Effects
(-)-Epigallocatechin gallate (EGCG), a polyphenolic compound, is the ester of epigallocatechin [E1084] and gallic acid [G0011]. EGCG has been found in a variety of plants including green and black tea plants, and reported to have diverse biological activities including antioxidant, anti-cancer, anti-angiogenic and cardiovascular protective effects. (The product is for research purpose only.)
References
PubMed Literature
Documents
Product Articles
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