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CAS RN: 95975-55-6 | Product Number: G0629
Guggulsterone [mixture of (E)- and (Z)- isomers]
![Thumbnail of Guggulsterone [mixture of (E)- and (Z)- isomers]](/medias/Tci-98-G0629.jpg?context=bWFzdGVyfHJvb3R8MzQ2M3xpbWFnZS9qcGVnfGFEZGtMMmczWWk4NU5EWXhPVEF6TnpVek1qUTJMMVJqYVMwNU9GOUhNRFl5T1M1cWNHY3wyNWZhMGFkNGY3MzhlNGQ0MzU5NGE1ZTVlYzJhOGIxNjBkZWFkZjE5ZDM3YTc4NGI4ZmViMjNjY2Y4YmFlODU2 "Guggulsterone [mixture of (E)- and (Z)- isomers]")
![Chemical Structure of Guggulsterone [mixture of (E)- and (Z)- isomers]](/medias/Tci-440-G0629.jpg?context=bWFzdGVyfHJvb3R8MjY0NjN8aW1hZ2UvanBlZ3xhREkyTDJnM1lpODVORFl4T1RBek56SXdORGM0TDFSamFTMDBOREJmUnpBMk1qa3VhbkJufGRmZWNiNmI4MmMzZDJlMDkwNmEyMmU3NzEzZjUzOTI4NzZhODUwMzJiYzZiZjllZWU1OGRlZTVkZmU2YmJlNDc "Guggulsterone [mixture of (E)- and (Z)- isomers]")
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Purity: >98.0%(HPLC)
Synonyms:
- Pregna-4,17(20)-diene-3,16-dione [mixture of (E)- and (Z)- isomers]
- Pregna-4,17-diene-3,16-dione [mixture of (E)- and (Z)- isomers]
Product Documents:
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| 250MG |
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| Product Number | G0629 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__1H__2__8O__2 = 312.45 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 95975-55-6 |
| Reaxys Registry Number | 5294518 |
| MDL Number | MFCD01310757 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 %(total of isomers) |
| NMR | confirm to structure |
Properties (reference)
GHS
Related Laws:
| RTECS# | TU3670500 |
Transport Information:
| H.S.code* | 2914.29-000 |
Application
Guggulsterone: A Bioactive Plant Sterol
Guggulsterone is a plant sterol and bioactive compound found in the gum guggul of Commiphora wightii, which has been used as a traditional herbal medicine. Guggulsterone has been reported to bind to the farnesoid X receptor (FXR), a member of the nuclear hormone receptor superfamily, and decrease the expression of bile acid-activated genes.1) Guggulsterone has been found to potently inhibit the activation of nuclear factor-κB (NF-κB), a critical regulator of inflammatory responses.1) Furthermore, guggulsterone modulates the expression of proteins with anti-apoptotic (IAP1, XIA, P, Bfl-1/A1, Bcl-2, cFLIP, survivin), cell survival, cell proliferation (cyclin D1, c-Myc), angiogenic, and metastatic (MMP-9, COX-2, VEGF) activities in tumor cells.1-5) (The product is for research purpose only.)
References
- 1) Guggulsterone inhibits NF-κB and IκBα kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis
- 2)Therapeutic effects of guggul and its constituent guggulsterone: cardiovascular benefits (a review)
- 3) Guggulsterone and Its Role in Chronic Diseases (a review)
- 4) Guggulsterone for Chemoprevention of Cancer (a review)
- 5) Pharmacologic activities of phytosteroids in inflammatory diseases: Mechanism of action and therapeutic potentials
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