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CAS RN: 5690-03-9 | Product Number: S0892
Splitomicin
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Purity: >98.0%(GC)
Synonyms:
- 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
$135.00
|
0 | 0 | It can be shipped in about 2 weeks after ordering | |
| 1G |
$432.00
|
9 | 0 | Contact Us |
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* The storage conditions are subject to change without notice.
| Product Number | S0892 |
Purity / Analysis Method 
|
>98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__3H__1__0O__2 = 198.22 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 5690-03-9 |
| Reaxys Registry Number | 161649 |
| PubChem Substance ID | 172089098 |
| MDL Number | MFCD08705254 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 53.0 to 57.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 55 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2932.20-000 |
Application
Splitomicin: A Potent Selective Inhibitor of Silent Information Regulator-2 (Sir2)
Silent Information Regulator-2 (Sir2) is a one of Class III histone deacetylases (HDACs) called Sirtuins. Splitomicin, which is derived from β-naphthol, is a potent selective inhibitor of Sir2. It inhibits nicotinamide adenine dinucleotide+ (NAD+) dependent histone deacetylase activity of Sir2.
References
- Identification of a small molecule inhibitor of Sir2p
- Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast
- Inhibitors of Sir2: Evaluation of Splitomicin Analogues
- Splitomicin suppresses human platelet aggregation via inhibition of cyclic AMP phosphodiesterase and intracellular Ca++ release
- Splitomicin inhibits fMLP-induced superoxide anion production in human neutrophils by activate cAMP/PKA signaling inhibition of ERK pathway
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