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CAS RN: 293754-55-9 | Product Number: T4241
T 0901317
×
Purity: >98.0%(HPLC)(qNMR)
Synonyms:
- N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 50MG |
$200.00
|
3 | 3 | It can be shipped in about 2 weeks after ordering |
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | T4241 |
Purity / Analysis Method 
|
>98.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__1__7H__1__2F__9NO__3S = 481.33 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 293754-55-9 |
| Reaxys Registry Number | 10385659 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 98.0 % |
| Melting point | 118.0 to 122.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 120 °C |
GHS
Related Laws:
| RTECS# | DB3192000 |
Transport Information:
| H.S.code* | 2935.90-000 |
Application
T 0901317: An Orally Active and Highly Selective LXR Agonist
Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid and glucose homeostasis. LXR agonists have been reported to be effective in the treatment of mouse models of atherosclerosis, diabetes and Alzheimer's disease. T 0901317 is an orally active and highly selective LXR agonist that induces apoptosis in cancer cells and inhibits the development of atherosclerosis in mice. (The product is for research use only.)
References
- Role of LXRs in control of lipogenesis
- T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice
- The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease
- Modulation of liver X receptor signaling as novel therapy for prostate cancer (a review)
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