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CAS RN: 761440-16-8 | Product Number: D5068
2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine
![Thumbnail of 2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine](/medias/D5068.jpg?context=bWFzdGVyfHJvb3R8MTgwNTh8aW1hZ2UvanBlZ3xhRFl5TDJnd1l5ODRPVE0wT0Rrd05qWTRNRFl5TDBRMU1EWTRMbXB3Wnd8ZGNlNTI1MDQ4MDhiOTI1ZmMxZmU5MGUwMGI2NjA2M2U2YzVmMGRhOTQ3ODAxYzNhNjMzMTgzNzM3NGEzNDc3NQ "2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine")
![Chemical Structure of 2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine](/medias/D5068.jpg?context=bWFzdGVyfHJvb3R8NjA1NTh8aW1hZ2UvanBlZ3xhRFEyTDJnME5TODRPVEl4TkRZNU1ESTJNek0wTDBRMU1EWTRMbXB3Wnd8NzgxZTM5NTNkZmViMDJmYjU1MDYwNDQ1ZDcyMDFhMjVhYjhiNGUxOTFhMzcyMjFmNDgwNjI2M2EzOTc4ZmNlOQ "2,5-Dichloro-N-[2-(isopropylsulfonyl)phenyl]pyrimidin-4-amine")
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Purity: >97.0%(HPLC)(N)
Synonyms:
Product Documents:
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| Product Number | D5068 |
Purity / Analysis Method 
|
>97.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__3H__1__3Cl__2N__3O__2S = 346.23 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 761440-16-8 |
| Reaxys Registry Number | 12052746 |
| PubChem Substance ID | 354333960 |
| MDL Number | MFCD12827956 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Melting point | 149.0 to 153.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 151 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2933.59-000 |
Application
A Synthetic Intermediate of Anaplastic Lymphoma Kinase (ALK) Inhibitors
This compound is used as a synthetic intermediate of anaplastic lymphoma kinase (ALK) inhibitors which have been reported their potential antitumor activities.
References
- Synthesis, Structure-Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials
- Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities
- Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing bicyclic aminobenzazepines for anaplastic lymphoma kinase (ALK) inhibitor
- Discovery of Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent Inhibitory Activities against Both Wild-type and Mutant ALK Kinases
PubMed Literature
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