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CAS RN: 6104-71-8 | Product Number: D5844
N-Desmethylclozapine
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Purity: >95.0%(GC)
Synonyms:
- Normethylclozapine
- Norclozapine
- 8-Chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
$141.00
|
1 | 13 | Contact Us | |
| 50MG |
$493.00
|
4 | 22 | Contact Us |
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| Product Number | D5844 |
Purity / Analysis Method 
|
>95.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__7H__1__7ClN__4 = 312.80 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 6104-71-8 |
| Reaxys Registry Number | 762289 |
| PubChem Substance ID | 468591599 |
| MDL Number | MFCD00210189 |
Specifications
| Appearance | White to Yellow powder to crystal |
| Purity(GC) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 177 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
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Transport Information:
| H.S.code* | 2933.59-000 |
Application
N-Desmethylclozapine: A Major Active Metabolite of the Atypical Antipsychotic Agent Clozapine
N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent clozapine [C2547]. N-Desmethylclozapine serves as an agonist to muscarinic 1 (M1) receptor, and is known to exert its antipsychotic action. (The product is for research purpose only.)
References
- N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity
- N-Desmethylclozapine: Is There Evidence for its Antipsychotic Potential? (a review)
- Determination of clozapine and its major metabolites in human serum using automated solid-phase extraction and subsequent isocratic high-performance liquid chromatography with ultraviolet detection
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