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CAS RN: 107724-20-9 | Product Number: E0905
Eplerenone
×
Purity: >98.0%(HPLC)
Synonyms:
- 9,11α-Epoxy-17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic Acid γ-Lactone Methyl Ester
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
$185.00
|
6 | 0 | It can be shipped in about 2 weeks after ordering |
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* The storage conditions are subject to change without notice.
| Product Number | E0905 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__4H__3__0O__6 = 414.50 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 107724-20-9 |
| Reaxys Registry Number | 7892318 |
| PubChem Substance ID | 160870987 |
| Merck Index (14) | 3625 |
| MDL Number | MFCD07783647 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 242 °C(dec.) |
| Maximum Absorption Wavelength | 240 nm |
| Solubility (soluble in) | Chloroform, dichloromethane |
| Solubility (slightly sol. in) | Ethanol |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2932.20-000 |
Application
Eplerenone: A Selective Mineralocorticoid Receptor Antagonist
Eplerenone is a mineralocorticoid receptor antagonist. It binds to the receptor and locks the binding of aldosterone, a component of the renin-angiotensin-aldosterone-system (RAAS). Aldosterone binds to mineralocorticoid receptors in tissues, and increases blood pressure through induction of sodium reabsorption and possibly other mechanisms. Eplerenone works by blocking the actions of aldosterone, and resulting in decreasing blood pressure. It is similar to spironolactone [S0260], though it is much more selective for the receptor in comparison. (The product is for research purpose only.)
References
- Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro
- Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats
- Effects of Long-Term Monotherapy With Eplerenone, a Novel Aldosterone Blocker, on Progression of Left Ventricular Dysfunction and Remodeling in Dogs With Heart Failure
- Cardioprotective mechanisms of eplerenone on cardiac performance and remodeling in failing rat hearts
- Molecular mechanisms of mineralocorticoid receptor antagonism by eplerenone (a review)
- A validated SPE-LC-MS/MS assay for Eplerenone and its hydrolyzed metabolite in human urine
- Stability-indicating RP-HPLC method for analysis of eplerenone in the bulk drug and in a pharmaceutical dosage form
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