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CAS RN: 64048-12-0 | Product Number: G0626
GANT 58
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Purity: >93.0%(qNMR)
Synonyms:
- 2,3,4,5-Tetra(4-pyridyl)thiophene
- 4-[2,4,5-Tri(4-pyridinyl)-3-thienyl]pyridine
- 4,4',4'',4'''-(Thiophene-2,3,4,5-tetrayl)tetrapyridine
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
$182.00
|
18 | 20 | It can be shipped in about 2 weeks after ordering |
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| Product Number | G0626 |
Purity / Analysis Method 
|
>93.0%(qNMR) |
| Molecular Formula / Molecular Weight | C__2__4H__1__6N__4S = 392.48 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 64048-12-0 |
| Reaxys Registry Number | 47834 |
| MDL Number | MFCD01103196 |
Specifications
| Appearance | White to Yellow to Orange powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(qNMR) | min. 93.0 % |
| Melting point | 249.0 to 253.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 250 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2934.99-000 |
Application
GANT 58: A Hedgehog/GLI (Hh/GLI) Signaling Pathway Inhibitor (Antagonist)
Hedgehog (Hh) signaling, which plays a critical role in cell proliferation and survival, has also been implicated in cancer initiation and progression. Glioma-associated oncogene (GLI) is an important nuclear transcription factor in Hh signaling and tumorigenesis. GANT 58 inhibits the Hedgehog/GLI (Hh/GLI) signaling pathway and induces apoptosis in cancer cell lines. (The product is for research purpose only.)
References
- Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
- Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells
- Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened (a review)
- Current trends in Hedgehog signaling pathway inhibition by small molecules (a review)
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