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CAS RN: 74103-07-4 | Product Number: K0053
Ketorolac Tromethamine
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Purity: >98.0%(T)(HPLC)
Synonyms:
- Ketorolac Tris Salt
- (±)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic Acid Tris Salt
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 1G |
$52.00
|
0 | 4 | Contact Us | |
| 5G |
$189.00
|
7 | 1 | Contact Us |
* Please contact our distributors or
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* The storage conditions are subject to change without notice.
| Product Number | K0053 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__3NO__3·C__4H__1__1NO__3 = 376.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 74103-07-4 |
| Related CAS RN
|
74103-06-3 |
| Reaxys Registry Number | 6463165 |
| PubChem Substance ID | 253661330 |
| Merck Index (14) | 5306 |
| MDL Number | MFCD00887595 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 167 °C |
| Maximum Absorption Wavelength | 322 nm (MeOH) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | UY7759900 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2933.99-000 |
Application
Ketorolac Tromethamine: A Non-Selective Cyclooxygenase (COX) Inhibitor with Strong Analgesic Activity
Ketorolac tromethamine is a non-steroidal anti-inflammatory drug (NSAID) with strong analgesic activity. Ketorolac is a non-selective cyclooxygenase (COX) inhibitor. Thus, it reduces prostaglandin synthesis. Ketorolac is the racemic mixture of (-)-S and (+)-R enantiomers. Most of its analgesic and COX inhibitory activity is retained in the S-isomer. Besides, some formulations for controlled release of ketorolac tromethamine have been reported. Ketorolac and its metabolites are excreted primarily by the kidneys. For your reference, [B4934] is used as a synthetic intermediate of ketorolac. (The product is for research purpose only.)
References
- The analgesic and anti-inflammatory profile of ketorolac and its tromethamine salt
- Ketorolac tromethamine absorption, distribution, metabolism, excretion, and pharmacokinetics in animals and humans
- Ketorolac. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential
- Semiinterpenetrating polymer network microspheres of gelatin and sodium carboxymethyl cellulose for controlled release of ketorolac tromethamine
- Ketorolac tromethamine formulations: an overview
- HPTLC determination of ketorolac tromethamine
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