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CAS RN: 82419-35-0 | Product Number: O0404
9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
![Chemical Structure of 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid](/medias/O0404.jpg?context=bWFzdGVyfHJvb3R8NTIyMjR8aW1hZ2UvanBlZ3xhRFUyTDJobU5pODRPVEl5T0RFeE5EWTFOelU0TDA4d05EQTBMbXB3Wnd8MWRiMjNhN2MzOWIyOWRlYzQ0ZjdhYzgxZmY3NTdmZjI2YzhiY2YwNGE4ODkxM2IyNjFkYjAwNzg4MTRlZjI0NQ "9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid")
![Thumbnail of 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid](/medias/O0404.jpg?context=bWFzdGVyfHJvb3R8MTYxMjd8aW1hZ2UvanBlZ3xhRE5oTDJnMFppODRPVE0yTWpjMk1ETXpOVFkyTDA4d05EQTBMbXB3Wnd8MTFjODhjZDkyY2U1NDY3YTFmMGFmY2Y0MTBkNTdlYTdlNWViMzUzNTE1MWMyNjNmNjdkNmM2MTIyNmE3MzA3Zg)
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![9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid](/_ui/responsive/theme-tci/images/missing_product_zoom.jpg "9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid")
Purity: >98.0%(HPLC)
Synonyms:
Product Documents:
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| 5G |
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| 25G |
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11 | 1 | Contact Us |
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| Product Number | O0404 |
Purity / Analysis Method 
|
>98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__3H__9F__2NO__4 = 281.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 82419-35-0 |
| Reaxys Registry Number | 4202751 |
| PubChem Substance ID | 253660701 |
| MDL Number | MFCD00226106 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Neutralization titration) | min. 97.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 311 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| H.S.code* | 2934.99-000 |
Application
フルオロキノロン系抗菌剤の合成
This compound has previously been converted into ofloxacin [O0403] and levofloxacin (an optically active ofloxacin) [L0193] by the reaction with 1-methylpiperazine [M0553]. To this day, it has been widely used for the synthesis of fluoroquinolone antibiotics.
References
- Synthesis and antibacterial activities of substituted 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids
- Synthesis and antibacterial activities of optically active ofloxacin
- Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids
- Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship
PubMed Literature
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