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CAS RN: 163451-81-8 | Product Number: T3287
Teriflunomide
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Purity: >98.0%(GC)
Synonyms:
- N-[4-(Trifluoromethyl)phenyl]-2-cyano-3-hydroxycrotonamide
- (Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
$105.00
|
1 | 28 | Contact Us | |
| 1G |
$577.00
|
9 | 23 | Contact Us |
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | T3287 |
Purity / Analysis Method 
|
>98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__2H__9F__3N__2O__2 = 270.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 163451-81-8 |
| Reaxys Registry Number | 6655982 |
| PubChem Substance ID | 253661385 |
| Merck Index (14) | 9165 |
| MDL Number | MFCD00910058 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 227.0 to 231.0 °C |
Properties (reference)
| Melting Point | 229 °C |
| Maximum Absorption Wavelength | 203 nm (MeOH) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
Transport Information:
| H.S.code* | 2926.90-000 |
Application
Teriflunomide: An Immunomodulatory Compound
Teriflunomide (A77 1726), the active metabolite of leflunomide [L0250], is an immunomodulatory compound. Teriflunomide has two activites: inhibition of pyrimidine nucleotide synthesis and interference with tyrosine phosphorylation. More specifically, it inhibits the enzymic activity of dihydroorotate dehydrogenase (DHO-DHase) which catalyzes the fourth step in the biosynthesis of pyrimidine, and tyrosine kinases which transfer a phosphate group from ATP to a protein in a cell. Teriflunomide reduces the proliferation of T and B immune cells that are active in multiple sclerosis (MS). For your reference, [C3217] is a synthetic intermediate. (The product is for research purpose only.)
References
- Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound
- The Immunosuppressive Metabolite of Leflunomide Is a Potent Inhibitor of Human Dihydroorotate Dehydrogenase
- The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms
- Teriflunomide and Its Mechanism of Action in Multiple Sclerosis (a review)
- Measurement of the active leflunomide metabolite (A77 1726) by reverse-phase high-performance liquid chromatography
- Quantitation of total and free teriflunomide (A77 1726) in human plasma by LC-MS/MS
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