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CAS RN: 181695-72-7 | Product Number: V0133
Valdecoxib
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Purity: >98.0%(HPLC)(N)
Synonyms:
- 4-(5-Methyl-3-phenyl-4-isooxazolyl)benzenesulfonamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
$108.00
|
15 | 2 | Contact Us | |
| 1G |
$366.00
|
2 | 0 | Contact Us |
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| Product Number | V0133 |
Purity / Analysis Method 
|
>98.0%(HPLC)(N) |
| Molecular Formula / Molecular Weight | C__1__6H__1__4N__2O__3S = 314.36 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 181695-72-7 |
| Reaxys Registry Number | 8563786 |
| Merck Index (14) | 9900 |
| MDL Number | MFCD00950568 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 98.0 % |
| Melting point | 169.0 to 173.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 170 °C |
| Maximum Absorption Wavelength | 202 nm (H__2O) |
| Solubility in water | Insoluble |
| Solubility (soluble in) | Ethanol, Methanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H361 : Suspected of damaging fertility or the unborn child. H373 : May cause damage to organs through prolonged or repeated exposure. H411 : Toxic to aquatic life with long lasting effects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. P260 : Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P391 : Collect spillage. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| RTECS# | DB2944030 |
Transport Information:
| UN Number | UN3077 |
| Class | 9 |
| Packing Group | III |
| H.S.code* | 2935.90-000 |
Application
Valdecoxib: A Selective Cyclo-Oxygenase-2 (COX-2) Inhibitor
Valdecoxib (SC 65872), a non-steroidal anti-inflammatory drug (NSAID), is a selective cyclo-oxygenase-2 (COX-2) inhibitor. In theory, a drug such as valdecoxib that selectively inhibited COX-2 might block inflammation, pain, and fever produced by prostaglandins while reducing the side effects (gastric erosions and ulcers) associated with inhibition of COX-1.
References
- 1. 4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib: A Potent and Selective Inhibitor of COX-2
- Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity
- Selective cyclooxygenase-2 inhibitors: similarities and differences (a review)
- Progress in COX-2 inhibitors: a journey so far (a review)
- Pharmacokinetics and metabolism of a COX-2 inhibitor, valdecoxib, in mice
- Determination of valdecoxib and its metabolites in human urine by automated solid-phase extraction-liquid chromatography-tandem mass spectrometry
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