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CAS RN: 274901-16-5 | Product Number: V0203
Vildagliptin
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Purity: >98.0%(T)(HPLC)
Synonyms:
- (S)-1-[[(1R,3R,5R,7S)-3-Hydroxyadamantan-1-yl]glycyl]pyrrolidine-2-carbonitrile
- (2S)-1-[N-(3-Hydroxytricyclo[3.3.1.13,7]decan-1-yl)glycyl]-2-pyrrolidinecarbonitrile
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
$90.00
|
10 | 0 | Contact Us | |
| 1G |
$314.00
|
14 | 0 | Contact Us |
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| Product Number | V0203 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__7H__2__5N__3O__2 = 303.41 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 274901-16-5 |
| Reaxys Registry Number | 9512439 |
| MDL Number | MFCD08275142 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 149.0 to 153.0 °C |
| Specific rotation | -84.0 to -90.0 deg(C=1, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 151 °C |
GHS
Related Laws:
| RTECS# | UY0281730 |
Transport Information:
| H.S.code* | 2933.99-000 |
Application
Vildagliptin：A Potent and Selective DPP-4 Inhibitor
Glucagon-like peptide 1 (GLP-1) is a gut-derived incretin hormone that stimulates insulin and suppresses glucagon secretion, inhibits gastric emptying, and reduces appetite and food intake. Dipeptidyl peptidase-4 (DPP-4) is an enzyme that breaks down GLP-1, limiting its effectiveness. Vildagliptin is a potent and selective DPP-4 inhibitor. Through this inhibition, vildagliptin increases the blood concentration of active GLP-1, and exerts its hypoglycemic effect through increasing insulin secretion and reducing glucagon secretion. (The product is for research use only.)
References
- Mechanisms of action of the dipeptidyl peptidase-4 inhibitor vildagliptin in humans (a review)
- Clinical pharmacokinetics and pharmacodynamics of vildagliptin
- Simultaneous determination of metformin and vildagliptin in human plasma by a HILIC-MS/MS method
- Physicochemical Properties and Methods of Analysis of Vildagliptin (Review)
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