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CAS RN: 81938-43-4 | Product Number: Z0041
Zofenopril Calcium
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Purity: >97.0%(HPLC)
Synonyms:
- (4S)-1-[(2S)-3-(Benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-L-proline Calcium Salt
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
$107.00
|
6 | 0 | It can be shipped in about 2 weeks after ordering | |
| 100MG |
$319.00
|
13 | 0 | It can be shipped in about 2 weeks after ordering |
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| Product Number | Z0041 |
Purity / Analysis Method 
|
>97.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__4__4H__4__4CaN__2O__8S__4 = 897.16 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 81938-43-4 |
| Reaxys Registry Number | 6466976 |
| PubChem Substance ID | 468593135 |
| Merck Index (14) | 10186 |
| MDL Number | MFCD11858294 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 97.0 area% |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 246 °C |
GHS
| Hazard Statements | H413 : May cause long lasting harmful effects to aquatic life. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P273 : Avoid release to the environment. |
Related Laws:
Transport Information:
| H.S.code* | 2933.99-000 |
Application
Zofenopril Calcium: An Angiotensin-Converting Enzyme (ACE) Inhibitor
Zofenopril calcium is an angiotensin-converting enzyme (ACE) inhibitor. Zofenopril is prodrug which is rapidly hydrolyzed to the active metabolite zofenoprilat by hepatic cleavage of the thioester group. It has been reported that zofenopril is characterized by high lipophilicity, selective cardiac ACE inhibition, and antioxidant and tissue protective activities. ACE, a peptidyl dipeptidase, circulates in the plasma and is located on the surface of endothelial cells. ACE is catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Thereby, ACE inhibitors reduce peripheral vascular resistance and blood pressure. For your reference, [B5315] is a key synthetic intermediate of zofenopril. (The product is for research purpose only.)
References
- Preclinical profile of zofenopril: an angiotensin converting enzyme inhibitor with peculiar cardioprotective properties (a review)
- Antioxidant and cardioprotective properties of the sulphydryl angiotensinconverting enzyme inhibitor zofenopril
- Simultaneous estimation and validation of some binary mixtures of antihypertensive drugs by RP-LC methods using two new generation silica columns
- Validated UV spectrophotometric method for quantification of zofenopril in pharmaceutical formulations
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