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CAS RN: 1620086-77-2 | Product Number: C3326
5-Chlorosaligenyl-N,N-diisopropylphosphoramidite
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Purity: >95.0%(T)
Synonyms:
- 6-Chloro-N,N-diisopropyl-4H-benzo[d][1,3,2]dioxaphosphinin-2-amine
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 200MG |
$90.00
|
14 | 0 | It can be shipped in about 2 weeks after ordering | |
| 1G |
$317.00
|
9 | 5 | It can be shipped in about 2 weeks after ordering |
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| Product Number | C3326 |
Purity / Analysis Method 
|
>95.0%(T) |
| Molecular Formula / Molecular Weight | C__1__3H__1__9ClNO__2P = 287.72 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Moisture Sensitive,Heat Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image), 200MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 1620086-77-2 |
| Reaxys Registry Number | 28732172 |
| PubChem Substance ID | 354334377 |
Specifications
| Appearance | White to Almost white powder to lump |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 45 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
Transport Information:
| H.S.code* | 2934.99-000 |
Application
Solid-phase Synthesis of DNA and RNA 5'-O-Triphosphates
After oligonucleotide synthesis:
5-Chloro-saligenyl-N,N-diisopropylphosphoramidite (Reagent I, C3326) is coupled to the 5'-end of the DMT-off oligonucleotide. Oxidation of the formed 5'-phosphite using the same oxidizing reagent used in standard oligonucleotide synthesis leads to support-bonded 5'-cycloSal-oligonucleotides. Reaction with pyrophosphate (Reagent II, B5440) yields the corresponding 5'-triphosphates. The 5'-triphosphorylated oligonucleotides are obtained after cleavage from the support in high purity and excellent yields. The whole reaction sequence was adapted to be used on a standard oligonucleotide synthesizer.
5-Chloro-saligenyl-N,N-diisopropylphosphoramidite (Reagent I, C3326) is coupled to the 5'-end of the DMT-off oligonucleotide. Oxidation of the formed 5'-phosphite using the same oxidizing reagent used in standard oligonucleotide synthesis leads to support-bonded 5'-cycloSal-oligonucleotides. Reaction with pyrophosphate (Reagent II, B5440) yields the corresponding 5'-triphosphates. The 5'-triphosphorylated oligonucleotides are obtained after cleavage from the support in high purity and excellent yields. The whole reaction sequence was adapted to be used on a standard oligonucleotide synthesizer.
References
- Solid-Phase Synthesis of DNA and RNA 5’-O-Triphosphates Using cycloSal Chemistry
PubMed Literature
Documents
Product Articles
[TCIMAIL No.183] New Reagents for the Synthesis of Triphosphates[Product Highlights] Phosphorous Compounds for the Synthesis of Triphosphonates of Oligonucleotides
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