Maintenance Notice (2:50 - 7:30 AM June 13, 2026 UTC): This website is scheduled to be unavailable due to maintenance. We appreciate your patience and understanding.
Product Document Searching Made Easy by 2D Code! | TCI Chemistry News June 2026 | [Product Highlights] Labeling Reagent for PET Imaging... | Various analytical charts can be searched on each product detail page and Product Document Search (The kinds of analytical charts differ by product)
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 24584-09-6 | Product Number: D4227
Dexrazoxane
×
Purity: >98.0%(T)
Synonyms:
- (S)-4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione)
- (S)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
$129.00
|
1 | 8 | Contact Us |
* Please contact our distributors or
TCI
to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | D4227 |
Purity / Analysis Method 
|
>98.0%(T) |
| Molecular Formula / Molecular Weight | C__1__1H__1__6N__4O__4 = 268.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 24584-09-6 |
| Reaxys Registry Number | 6658412 |
| PubChem Substance ID | 160871504 |
| Merck Index (14) | 8123 |
| MDL Number | MFCD00866449 |
Specifications
| Appearance | White to Light yellow to Light orange powder to crystal |
| Purity(Neutralization titration) | min. 98.0 % |
| Melting point | 193.0 to 197.0 °C |
| Specific rotation [a]20/D | +10.0 to +13.0 deg(C=5、DMF) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 195 °C |
| Specific Rotation | 11° (C=5,DMF) |
| Solubility (soluble in) | Dimethylformamide |
| Solubility (slightly sol. in) | Methanol, Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P305 + P351 + P338 : IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | TL6390000 |
Transport Information:
| H.S.code* | 2933.59-000 |
Application
Studies on the Topoisomerase II Inhibitory Effects of Dexrazoxane
References
- Cell cycle progression and chromosome segregation in mammalian cells cultured in the presence of the topoisomerase II inhibitors ICRF-187 [(±)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane; ADR-529] and ICRF-159 (Razoxane)
- G. J. Gorbsky, Cancer Res. 1994, 54, 1042.
- Mapping of DNA topoisomerase II poisons (etoposide, clerocidin) and catalytic inhibitors (aclarubicin, ICRF-187) to four distinct steps in the topoisomerase II catalytic cycle
- A novel mechanism of cell killing by anti-topoisomerase II bisdioxopiperazines
- A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane)
- Topoisomerase IIbeta-Mediated DNA Double-Strand Breaks: Implications in Doxorubicin Cardiotoxicity and Prevention by Dexrazoxane
Application
Studis of Cardiotoxicity Reduction
References
- Daunorubicin-induced apoptosis in rat cardiac myocytes is inhibited by dexrazoxane
- Chemical, biological and clinical aspects of dexrazoxane and other bisdioxopiperazines
- B. B. Hasinoff, K. Hellmann, E. H. Herman, V. J. Ferrans, Curr. Med. Chem. 1998, 5, 1.
PubMed Literature
Product Articles
Product Documents (Note: Some products will not have analytical charts available.)
Enter TCI Product Number
Enter KISHIDA Product Number
4-5 alphanumeric characters before the hyphen
7 alphanumeric characters
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
• The requested SDS is not available.
Specifications
The requested specifications are not available.
Please Contact Us for more information.
The requested specifications are not available.
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Incorrect Lot Number. Please input only the 7 alphanumeric characters.
• Please check that the lot number you have entered is correct. It is 4-5 alphanumeric characters before the hyphen. In particular, please check O (letter) or 0 (number) and I (letter) or 1 (number).
• If your information is correct and you are still not able to view the requested certificates, Please Contact Us for more information.
• Please check that the lot number you have entered is correct. It is 7 alphanumeric characters. In particular, please check O (letter) or 0 (number) and I (letter) or 1 (number).
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Incorrect Lot Number. Please input only the 7 alphanumeric characters.
The requested analytical chart is not available. Sorry for the inconvenience.