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CAS RN: 1229-29-4 | Product Number: D4626
Doxepin Hydrochloride (mixture of isomers)
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo[b,e]oxepine Hydrochloride (mixture of isomers)
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
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|---|---|---|---|---|---|
| 1G |
$45.00
|
9 | 0 | It can be shipped in about 2 weeks after ordering | |
| 5G |
$132.00
|
31 | 1 | It can be shipped in about 2 weeks after ordering | |
| 25G |
$394.00
|
2 | 9 | Contact Us |
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| Product Number | D4626 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__2__1NO·HCl = 315.84 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 1229-29-4 |
| Related CAS RN
|
1668-19-5 |
| Reaxys Registry Number | 5463221 |
| PubChem Substance ID | 253662533 |
| Merck Index (14) | 3435 |
| MDL Number | MFCD00079135 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 %(total of isomers) |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 186.0 to 190.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 188 °C |
| Maximum Absorption Wavelength | 298 nm |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | HQ4375000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| H.S.code* | 2932.99-000 |
Application
Doxepin Hydrochloride: A Monoamine Reuptake Inhibitor with a Wide Range of Pharmacological Properties
Doxepin hydrochloride has a wide range of pharmacological properties including an antinoradrenergic property. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H1 and H2 receptors. Doxepin hydrochloride is a family of tricyclic antidepressant agents such as amitriptyline hydrochloride [A0908] and imipramine hydrochloride. (The product is for research purpose only.)
References
- Doxepin up-to-date: a review of its pharmacological properties and therapeutic efficacy with particular reference to depression
- Tricyclic antidepressants as long-acting local anesthetics
- Role of cytochrome P450 2D6 (CYP2D6) in the stereospecific metabolism of E- and Z-doxepin
- Structure of the human histamine H1 receptor complex with doxepin
- Spectrofluorimetric method for the determination of doxepin hydrochloride in commercial dosage forms
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