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CAS RN: 196597-26-9 | Product Number: R0216
Ramelteon
×
Purity: >98.0%(GC)
Synonyms:
- (S)-N-[2-(2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-yl)ethyl]propionamide
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
$112.00
|
13 | 18 | Contact Us | |
| 1G |
$696.00
|
1 | 9 | Contact Us |
* Please contact our distributors or
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to order our products. The above prices do not include freight cost, customs, and other charges to the destination.
* The storage conditions are subject to change without notice.
| Product Number | R0216 |
Purity / Analysis Method 
|
>98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__6H__2__1NO__2 = 259.35 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Packaging and Container
|
100MG-Glass Bottle with Plastic Insert (View image), 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 196597-26-9 |
| Reaxys Registry Number | 9277585 |
| PubChem Substance ID | 468592788 |
| Merck Index (14) | 8101 |
| MDL Number | MFCD08067736 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 114.0 to 118.0 °C |
| Specific rotation [a]20/D | -55.0 to -60.0 deg(C=1, CHCL3) |
Properties (reference)
| Melting Point | 116 °C |
| Specific Rotation | -57° (C=1,CHCl3) |
| Solubility in water | Insoluble |
| Degree of solubility in water | 11 mg/l 25 °C |
| Solubility (soluble in) | Ethanol |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H361 : Suspected of damaging fertility or the unborn child. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | TX1498230 |
Transport Information:
| H.S.code* | 2932.99-000 |
Application
Ramelteon: A Selective Melatonin MT1 and MT2 Receptors Agonist
Ramelteon (TAK-375) is a melatonin [M1105] receptor agonist with both high affinity for melatonin MT1 and MT2 receptors, and high selectivity for MT1 and MT2 receptors compared to the MT3 receptor. In addition, ramelteon showed no measurable affinity for a large number of ligand binding sites, including benzodiazepine receptors, dopamine receptors, opiate receptors, ion channels, and transporters. Ramelteon also does not interfere with the activity of a number of enzymes. The agonist activity at the MT1 and MT2 receptors has been reported to contribute to its sleep-promoting properties. And then, ramelteon currently is approved in the United States and Japan for the treatment of insomnia. (The product is for research purpose only.)
References
- Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist
- Pharmacology of ramelteon, a selective MT1/MT2 receptor agonist: a novel therapeutic drug for sleep disorders (a review)
- Enantiomeric separation of a melatonin agonist Ramelteon using amylose-based chiral stationary phase
- メラトニン受容体作動薬ラメルテオン (ロゼレム®錠8 mg) の薬理作用と臨床試験成績
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