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CAS RN: 138046-43-2 | Product Number: Y0032
YM-750
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Purity: >93.0%(HPLC)(qNMR)
Synonyms:
- 1-[(9H-Fluoren-2-yl)methyl]-1-cycloheptyl-3-mesitylurea
- 1-Cycloheptyl-1-(9H-fluoren-2-ylmethyl)-3-mesitylurea
Product Documents:
| Size | Unit Price | Same Day | 2-3 Business Days | Other Lead Time |
Shipping Information
|
|---|---|---|---|---|---|
| 20MG |
$137.00
|
29 | 0 | It can be shipped in about 2 weeks after ordering |
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* The storage conditions are subject to change without notice.
| Product Number | Y0032 |
Purity / Analysis Method 
|
>93.0%(HPLC)(qNMR) |
| Molecular Formula / Molecular Weight | C__3__1H__3__6N__2O = 452.64 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 138046-43-2 |
| Reaxys Registry Number | 8368179 |
| MDL Number | MFCD00905424 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 93.0 area% |
| Purity(qNMR) | min. 93.0 % |
| Melting point | 96.0 to 100.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 99 °C |
GHS
Related Laws:
Transport Information:
| H.S.code* | 2924.29-000 |
Application
YM-750: A Potent and Selective Inhibitor of Acyl-Coenzyme A
Acyl-Coenzyme A (ACAT, also known as sterol O-acyltransferase or SOAT) is an intracellular enzyme that catalyzes the formation of cholesteryl esters from cholesterol and fatty acyl-CoA.1) Recently, many studies have suggested that ACAT-1 (SOAT-1) plays a critical role in cancer initiation and progression and is an attractive target for novel anticancer therapies.2) This product, YM-750, is a potent and selective inhibitor of ACAT.1,3,4) (The product is for research use only.)
References
- 1) Targeting Sterol O-Acyltransferase/Acyl-CoA:Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential (a review)
- 2) Cholesterol metabolism: New functions and therapeutic approaches in cancer (a review)
- 3) YM750, an ACAT Inhibitor, Acts on Adrenocortical Cells to Inhibit Aldosterone Secretion Due to Depolarization
- 4) Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam cells
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