Stable Fluorinating Reagent with Ease of Handling “FLUOLEAD™"

4-tert-Butyl-2,6-dimethylphenylsulfur trifluoride (FLUOLEAD™, 1), which was first reported by Umemoto et al., is a novel nucleophilic fluorinating reagent. Differing from other existing fluorinating reagents, such as DAST, FLUOLEAD™ is a crystalline solid with high thermal stability and less fuming character, which makes it easier to handle. FLUOLEAD^TM fluorinates a hydroxy or carbonyl group to afford the corresponding fluorinated compounds in good yields.