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Adenylate Cyclase Activator
No.167(October 2015)
Forskolin (1) is a diterpenoid from the Indian plant, Coleus forskolii.1) 1 activates adenylate cyclase.2,3) 1 induces differentiation of mesenchymal stem cells into neuron-like cells.4) Recently, 1 was utilized for establishing chemically induced pluripotent stem cells (iPSCs) as one of the chemical “substitutes” of Oct4, which is one of four transcription factors (Oct4, Klf4, Sox2, and c-Myc or Oct4, Sox2, Nanog, and Lin28).5)
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References
- 1)On the high value medicinal plant, Coleus forskohlii Briq
- M. Paul, A. Radha, D. S. Kumar, Hygeia J. D. Med. 2013, 5, 69.
- 2)Interactions of forskolin and adenylate cyclase. Effects on substrate kinetics and protection against inactivation by heat and N-ethylmaleimide
- 3)Forskolin: A labdane diterpenoid with antihypertensive, positive inotropic, platelet aggregation inhibitory, and adenylate cyclase activating properties
- 4)cAMP induces neuronal differentiation of mesenchymal stem cells via activation of extracellular signal-regulated kinase/MAPK
- 5)Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds
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