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CAS RN: 5638-76-6 | Product Number: B6621
Betahistine
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Purity: >98.0%(GC)(T)
Synonyms:
- 2-(2-Methylaminoethyl)pyridine
- N-Methyl-2-(2-pyridinyl)ethanamine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
€61.00
|
Ships within 3 weeks after ordering | 7 |
|
|
| 25G |
€226.00
|
Contact Us | 13 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | B6621 |
Purity / Analysis Method 
|
>98.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__8H__1__2N__2 = 136.20 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| CAS RN | 5638-76-6 |
| Reaxys Registry Number | 112294 |
| MDL Number | MFCD00006362 |
Specifications
| Appearance | Colorless to Yellow to Orange clear liquid |
| Purity(GC) | min. 98.0 % |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Boiling Point | 114 °C/30 mmHg |
| Flash point | 96 °C |
| Specific Gravity (20/20) | 0.99 |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 227-086-4 |
| RTECS# | UT5552000 |
Transport Information:
| HS Number | 2933399999 |
Application
Betahistine: A Histamine H1 Receptor Agonist/H3 Antagonist
Betahistine and its methanesulfonate [B1424] are structural analogs of histamine [H0146, dihydrochloride] that act as both partial histamine H1-receptor agonists and histamine H3 receptor antagonists in neuronal tissue. Betahistine increases histamine turnover and release by blocking presynaptic H3-receptors and inducing H3-receptor downregulation.1-3) Betahistine has been reported to increase vestibular blood flow and is used clinically as an antivertigo agent.2,3) Recently, it has been reported that betahistine induced the recall of forgotten memories in mice.4) (The product is for research use only.)
References
- 1) Actions of betahistine at histamine receptors in the brain
- 2) Betahistine increases vestibular blood flow
- 3) Histamine and betahistine in the treatment of vertigo: Elucidation of mechanisms of action (a review)
- 4) Central Histamine Boosts Perirhinal Cortex Activity and Restores Forgotten Object Memories
- 5) LC-MS-MS analysis of 2-pyridylacetic acid, a major metabolite of betahistine: application to a pharmacokinetic study in healthy volunteers
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