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Published TCIMAIL newest issue No.199
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CAS RN: 104376-79-6 | Product Number: C2226
Ceftriaxone Disodium Salt Hemiheptahydrate
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Purity: >98.0%(T)(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 5G |
€61.00
|
35 | ≥100 |
|
| 25G |
€210.00
|
1 | 23 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
Supplemental Product Information:
This product has not been tested for potency and is guaranteed for chemical purity.
| Product Number | C2226 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__8H__1__6N__8Na__2O__7S__3·3^^1/__2H__2O = 661.58 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Condition to Avoid | Light Sensitive |
| CAS RN | 104376-79-6 |
| Related CAS RN
|
73384-59-5&74578-69-1 |
| Reaxys Registry Number | 9110623 |
| PubChem Substance ID | 87560125 |
| MDL Number | MFCD00941454 |
Specifications
| Appearance | White to Orange to Green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Specific rotation [a]20/D | -150 to -170 deg(C=1, H2O)(calcd.on anh.substance) |
| Water | 8.0 to 11.0 % |
Properties (reference)
| Melting Point | 236 °C |
| Specific Rotation | -160° (C=1,H2O) |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. H317 : May cause an allergic skin reaction. H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled. |
| Precautionary Statements | P261 : Avoid breathing dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P284 : Wear respiratory protection. P342 + P311 : If experiencing respiratory symptoms: Call a POISON CENTER/doctor. P304 + P340 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. |
Related Laws:
| RTECS# | XI0368800 |
Transport Information:
| HS Number | 2941900000 |
Application
Ceftriaxone Disodium: A Third Generation Semisynthetic Cephalosporin Antibiotic with Longer Serum Half-Life
Ceftriaxone disodium salt is a third generation semisynthetic cephalosporin antibiotic, which is chemically synthesized form 7-aminocephalosporanic acid (7-ACA) [A1266]. It has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria, and is generally more active against Gram-negative bacteria than the first and second generation cephalosporins. It has increased stability to β-lactamases compared with the first and second generation cephalosporins. Incorporation of the triazine substituted side chain into the 3-position of the cephalosporin nucleus markedly prolong serum half-life.
References
- Ceftriaxone: a review of its antibacterial activity, pharmacological properties and therapeutic use
- Ceftizoxime and other third-generation cephalosporins: structure-activity relationships
- Ceftriaxone: a beta-lactamase-stable, broad-spectrum cephalosporin with an extended half-life
- Ceftriaxone (an update of its use in the management of community-acquired and nosocomial infections)
- Solubility and Density of the Disodium Salt Hemiheptahydrate of Ceftriaxone in Water + Ethanol Mixtures
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