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Published TCIMAIL newest issue No.199

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Published TCIMAIL newest issue No.199

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CAS RN: 58880-19-6 | Product Number: T2477

Trichostatin A

Purity: >98.0%(HPLC)

Synonyms:

TSA
[R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

Product Documents:

Size	Unit Price	Belgium	Japan*	Quantity
10MG	306,00 €	2	≥80
50MG	1 146,00 €	2	18

*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).

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General Information plus

Specifications & Properties plus

Specifications

Appearance	White to Orange to Green powder to crystal
Purity(HPLC)	min. 98.0 area%
Optical purity(LC)	min. 95.0 ee%
NMR	confirm to structure

Properties (reference)

Melting Point	144 °C(dec.)
Specific Rotation	136° (C=0.3,MeOH)
Solubility (slightly sol. in)	Alcohol

Safety & Regulations plus

GHS

Pictogram
Signal Word	Warning
Hazard Statements	H302 + H312 + H332 : Harmful if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation.
Precautionary Statements	P261 : Avoid breathing dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell. P304 + P340 + P312 : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell.

Related Laws:

RTECS#

MI5215000

Transport Information:

HS Number

2928009090

Applications & Literature plus

Application

Trichostatin A: A Potent Inhibitor of Histone Deacetylases (HDACs) with Potent Antitumor Activity

Trichostatin A(R-enantiomer) was originally developed as an antifungal antibiotic agent isolated from the metabolites of strains of Streptomyces hygroscopicus in 1976.¹⁾ From the 1980s onwards, it has been reported that trichostatin A is a potent inhibitor of histone deacetylases (HDACs) with potent antitumor activity.^2-7) Trichostatin A causes the induction of cell differentiation and specific inhibition of the cell cycle in the G₁ and G₂ phases at the very low concentrations.For your reference, trichostatin A (R-enantiomer) is the more active enantiomer (eutomer) of (-)-trichostatin A (S-enantiomer) [T3633] (The product is for research purpose only.)

References

1)A new antifungal antibiotic, trichostatin
- N. Tsuji, M. Kobayashi, K. Nagashima, Y. Wakisaka, K. Koizumi, J. Antibiot. 1976, 29, 1.
2)Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A
- M. Yoshida, M. Kijima, M. Akita, T. Beppu, J. Biol. Chem. 1990, 265, 17174.
3)Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
- M. S. Finnin, J. R. Donigian, A. Cohen, V. M. Richon, R. A. Rifkind, P. A. Marks, R. Breslow, N. P. Pavletich, Nature 1999, 401, 188.
4)Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function (a review)
- M. Yoshida, S. Horinouchi, T. Beppu, BioEssays 1995, 17, 423.
5)The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells (a review)
- W.-G. Zhu, G. A. Otterson, Curr. Med. Chem. Anti-Canc. Agents 2003, 3, 187.
6)Trichostatin A - like hydroxamate histone deacetylase inhibitors as therapeutic agents: Toxicological point of view (a review)
- T. Vanhaecke, P. Papeleu, G. Elaut, V. Rogiers, Curr. Med. Chem. 2004, 11, 1629.
7)Zn(II)-dependent histone deacetylase inhibitors: Suberoylanilide hydroxamic acid and trichostatin A
- R. Codd, N. Braich, J. Liu, C. Z. Soe, A. A. H. Pakchung, Int. J. Biochem. Cell Biol. 2009, 41, 736.

Application

iPS cell generation boosting compounds

Reference

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
- D. Huangfu, R. Maehr, W. Guo, A. Eijkelenboom, M. Snitow, A. E. Chen, D. A. Melton, Nat. Biotechnol. 2008, 26, 795.

PubMed Literature

Documents

Epigenetics Research Reagents

Regenerative Medicine Research Reagents

Antimicrobials and Antitumors for Research and Experimental Use

Pharmaceutical Ingredients for Research and Experimental Use

Product Articles

Product Documents (Note: Some products will not have analytical charts available.)

Safety Data Sheet (SDS)

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Specifications

C of A & Other Certificates

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Analytical Charts

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Product Number	T2477
Purity / Analysis Method	>98.0%(HPLC)
Molecular Formula / Molecular Weight	C__1__7H__2__2N__2O__3 = 302.37
Physical State (20 deg.C)	Solid
Storage Temperature	Frozen (<0°C)
Condition to Avoid	Heat Sensitive
Packaging and Container	10MG-Glass Bottle with Plastic Insert (View image), 50MG-Glass Bottle with Plastic Insert (View image)
CAS RN	58880-19-6
Reaxys Registry Number	2391788
PubChem Substance ID	87560260
Merck Index (14)	9649
MDL Number	MFCD03848392

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CAS RN: 58880-19-6 | Product Number: T2477