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Published TCIMAIL newest issue No.201
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CAS RN: 10537-47-0 | Product Number: T3667
Tyrphostin A9
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Purity: >98.0%(GC)
Synonyms:
- Malonoben
- [4-Hydroxy-3,5-bis(2-methyl-2-propanyl)benzylidene]malononitrile
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
51,00 €
|
2 | 4 |
|
|
| 100MG |
154,00 €
|
Contact Us | 11 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | T3667 |
Purity / Analysis Method 
|
>98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__8H__2__2N__2O = 282.39 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 10537-47-0 |
| Reaxys Registry Number | 2700764 |
| PubChem Substance ID | 468592884 |
| MDL Number | MFCD00209853 |
Specifications
| Appearance | Light orange to Yellow to Green powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 139.0 to 147.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 140 °C |
| Maximum Absorption Wavelength | 464 nm (EtOH) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 + H311 + H331 : Toxic if swallowed, in contact with skin or if inhaled. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P261 : Avoid breathing dust. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P302 + P352 + P312 : IF ON SKIN: Wash with plenty of water. Call a POISON CENTER/doctor if you feel unwell. P403 + P233 : Store in a well-ventilated place. Keep container tightly closed. |
Related Laws:
| RTECS# | OO3737000 |
Transport Information:
| UN Number | UN3439 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2926907090 |
Application
Type IV secretion system (T4SS) research
Reference
- Chemical Genetics Reveals Bacterial and Host Cell Functions Critical for Type IV Effector Translocation by Legionella pneumophila
Application
Tyrphostin A9: A Tyrosine Kinase Inhibitor
Tyrphostin A9 (other names in the references: Malonoben, Tyrphostin AG17 or SF6847) is a tyrosine kinase inhibitor originally synthesized as a potential anticarcinogenic compound. Reportedly, tyrphostin A9 selectively inhibits the activity of a platelet-derived growth factor receptor (PDGFR) protein1), the growth of vascular smooth muscle cells1), the growth of cancer cells2,3), and the phosphorylation of tyrosine1,2,4,5).
References
- 1)Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells
- 2)STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis
- 3)Tyrphostin AG17, [(3,5-Di-tert-butyl-4-hydroxybenzylidene)-malononitrile], inhibits cell growth by disrupting mitochondria
- 4)Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF
- 5)Tyrphostin A9 inhibits calcium release-dependent phosphorylations and calcium entry via calcium release-activated channel in Jurkat T cells
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