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Published TCIMAIL newest issue No.198
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CAS RN: 71369-59-0 | Product Number: T4139
(-)-Talinolol
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Purity: >95.0%(T)(HPLC)
Synonyms:
- (S)-1-[4-[3-(tert-Butylamino)-2-hydroxypropoxy]phenyl]-3-cyclohexylurea
- 1-[4-[(2S)-3-(tert-Butylamino)-2-hydroxypropoxy]phenyl]-3-cyclohexylurea
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 20MG |
€140.00
|
1 | 33 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | T4139 |
| Purity / Analysis Method | >95.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__0H__3__3N__3O__3 = 363.50 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 71369-59-0 |
| Related CAS RN | 57460-41-0 |
| Reaxys Registry Number | 8353028 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Purity(Nonaqueous Titration) | min. 95.0 % |
| Melting point | 142.0 to 146.0 °C |
| Specific rotation | -9.0 to -11.0 deg(C=0.1, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 144 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2924297099 |
Application
(-)-Talinolol: A Model Compound for P-Glycoprotein Drug-Drug Interaction Studies
(±)-Talinolol, a β1-selective adrenoceptor antagonist, has been used as a suitable model compound for P-glycoprotein drug-drug interaction studies due to its P-glycoprotein-related active intestinal secretion and lack of any significant metabolism.1,2) (-)-Talinolol is the active (S)-isomer as a β1-selective adrenoceptor antagonist, and can also be used as a model compound for the studies.3,4) (The product is for research purpose only.)
References
- 1) Induction of P-glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: a new type of drug/drug interaction
- 2) P-glycoprotein inhibitor erythromycin increases oral bioavailability of talinolol in humans
- 3) Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers: concentration- and dose-dependent absorption in vitro and in vivo
- 4) Grapefruit juice enhances intestinal absorption of the P-glycoprotein substrate talinolol (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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