Published TCIMAIL newest issue No.201
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 141396-28-3 | Product Number: A2705
Argatroban Monohydrate
×
Purity: >99.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 25MG |
€108.00
|
Contact Us | Contact Us |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | A2705 |
Purity / Analysis Method 
|
>99.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__3__6N__6O__5S·H__2O = 526.66 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Light Sensitive,Heat Sensitive |
| CAS RN | 141396-28-3 |
| Related CAS RN
|
74863-84-6 |
| PubChem Substance ID | 253661816 |
| Merck Index (14) | 779 |
| MDL Number | MFCD00895735 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 99.0 area% |
| Elemental analysis(Nitrogen) | 15.50 to 16.50 % |
| Specific rotation [a]20/D | +160.0 to +170.0 deg(C=0.8, MeOH)(calcd.on anh.substance) |
| Water | 2.5 to 4.5 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 180 °C(dec.) |
| Specific Rotation | 165° (C=0.8,MeOH) |
| Solubility in water | Insoluble |
| Solubility (slightly sol. in) | Methanol |
| Solubility (insoluble in) | Ether, Acetone |
GHS
Related Laws:
| RTECS# | TM6126625 |
Transport Information:
| HS Number | 2935909099 |
Application
Argatroban: A Direct Thrombin Inhibitor Act as an Anticoagulant
Argatroban is a synthetic selective thrombin inhibitor. It is known that argatroban exerts inhibiting activities on fibrin generation, platelet aggregation and vasoconstriction by direct interacting with thrombin. Due to these activities, argatoroban is utilized as an ingredient for anticoagulant and antithrombotic. Argatroban is also used as one of positive control drugs for thrombosis model animals. (This product is for research purpose only.)
References
- Comparative study on heparin and a synthetic thrombin inhibitor no. 805 (MD-805*) in experimental antithrombin III-deficient animals
- Potent inhibition of thrombin by the newly synthesized arginine derivative No. 805. The importance of stereo-structure of its hydrophobic carboxamide portion
- Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[1,2,3,4-tetrahydro-8-quinolinyl)sulfonyl]-L-arginyl]-2-piperidinecarboxylic acid
- Antithrombotic actions of argatroban in rat models of venous, 'mixed' and arterial thrombosis, and its effects on the tail transection bleeding time
- Effects of a thrombin inhibitor, argatroban, on ischemic brain damage in the rat distal middle cerebral artery occlusion model.
- Argatroban (a review)
- Direct thrombin inhibitors in acute coronary syndromes: present and future (a review)
- Argatroban: Update (a review)
PubMed Literature
Product Documents (Note: Some products will not have analytical charts available.)
Enter TCI Product Number
Enter KISHIDA Product Number
4-5 alphanumeric characters before the hyphen
7 alphanumeric characters
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
• The requested SDS is not available.
Specifications
The requested specifications are not available.
Please Contact Us for more information.
The requested specifications are not available.
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Incorrect Lot Number. Please input only the 7 alphanumeric characters.
• Please check that the lot number you have entered is correct. It is 4-5 alphanumeric characters before the hyphen. In particular, please check O (letter) or 0 (number) and I (letter) or 1 (number).
• If your information is correct and you are still not able to view the requested certificates, Please Contact Us for more information.
• Please check that the lot number you have entered is correct. It is 7 alphanumeric characters. In particular, please check O (letter) or 0 (number) and I (letter) or 1 (number).
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Incorrect Lot Number. Please input only the 7 alphanumeric characters.
The requested analytical chart is not available. Sorry for the inconvenience.