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Published TCIMAIL newest issue No.201
Maximum quantity allowed is 999
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CAS RN: 921902-48-9 | Product Number: K0077
KN3014
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- N-[2-(1-Methyl-1,2,3,4-tetrahydroquinolin-6-yl)-2-(piperidin-1-yl)ethyl]-2-(o-tolyloxy)acetamide
- 2-(2-Methylphenoxy)-N-[2-(1-methyl-1,2,3,4-tetrahydro-6-quinolinyl)-2-(1-piperidinyl)ethyl]acetamide
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 10MG |
€36.00
|
Contact Us | ≥40 |
|
|
| 50MG |
€143.00
|
Contact Us | ≥40 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | K0077 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__6H__3__5N__3O__2 = 421.59 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 921902-48-9 |
| Reaxys Registry Number | 38211687 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 136.0 to 140.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 138 °C |
GHS
Related Laws:
Transport Information:
| HS Number | 2933499090 |
Application
KN3014: A Small Compound Targeting the Interaction between NLRP3-PYD and ASC-PYD of the NLRP3 Inflammasome
KN3014, developed by Masumoto et al, is a small compound containing a piperidine ring that directly inhibits the interaction between the PYDs (pyrin domains) of NLRP3 and ASC (apoptosis associated speck-like protein containing a caspase recruitment domain) by protein-protein interaction inhibition screening of wheat germ cell-free synthesized proteins.
References
- KN3014, a piperidine-containing small compound, inhibits auto-secretion of IL-1β from PBMCs in a patient with Muckle–Wells syndrome
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