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Published TCIMAIL newest issue No.201
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CAS RN: 1485-00-3 | Product Number: M3390
MNS
×
Purity: >98.0%(GC)
Synonyms:
- 3,4-Methylenedioxy-β-nitrostyrene
- 5-(2-Nitrovinyl)-1,3-benzodioxole
- 5-(2-nitrovinyl)benzo[d][1,3]dioxole
- MDBN
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 100MG |
€35.00
|
Contact Us | 10 |
|
|
| 500MG |
€122.00
|
Contact Us | 13 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | M3390 |
Purity / Analysis Method 
|
>98.0%(GC) |
| Molecular Formula / Molecular Weight | C__9H__7NO__4 = 193.16 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Light Sensitive,Air Sensitive,Heat Sensitive |
| CAS RN | 1485-00-3 |
| Reaxys Registry Number | 15499 |
| PubChem Substance ID | 468592438 |
| MDL Number | MFCD00014575 |
Specifications
| Appearance | Light yellow to Yellow to Green powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 159.0 to 163.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 161 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| RTECS# | WL5270000 |
Transport Information:
| HS Number | 2932990090 |
Application
MNS: A Potent Antiplatelet Agent with Tyrosine Kinase Inhibitory Activity, and a NLRP3 Inflammasome Inhibitor
MNS, the β-nitrostyrene derivative, is a potent antiplatelet agent with tyrosine kinase inhibitory activity.1,2) It has recently been reported that NLR family pyrin domain-containing protein 3 (NLRP3), a pattern recognition receptor, forms a complex called NLRP3 inflammasome in response to irritating metabolites and pathogens, and induces the production of pro-inflammatory cytokines, Interleukin (IL)-1β and IL-18. MNS has also attracted attention as a NLRP3 inflammasome inhibitor which shows anti-inflammatory activity.3,4) (The product is for research purpose only.)
References
- 1) Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-β-nitrostyrene, a novel tyrosine kinase inhibitor
- 2) Synthesis and pharmacological evaluation of novel β-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity
- 3) 3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome
- 4) 3,4-Methylenedioxy-β-Nitrostyrene Ameliorates Experimental Burn Wound Progression by Inhibiting the NLRP3 Inflammasome Activation
Documents
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