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CAS RN: 4345-03-3 | Product Number: T2628
D-α-Tocopherol Succinate
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Purity: >97.0%(GC)(T)
Synonyms:
- Vitamin E Succinate
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 5G |
€23.00
|
2 | ≥100 |
|
|
| 25G |
€78.00
|
1 | ≥60 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | T2628 |
Purity / Analysis Method 
|
>97.0%(GC)(T) |
| Molecular Formula / Molecular Weight | C__3__3H__5__4O__5 = 530.79 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 4345-03-3 |
| Reaxys Registry Number | 65995 |
| PubChem Substance ID | 253661999 |
| Merck Index (14) | 9495 |
| MDL Number | MFCD00072055 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 97.0 % |
| Purity(Neutralization titration) | min. 97.0 % |
| Melting point | 73.0 to 77.0 °C |
| Specific rotation [a]20/D | +3.0 to +5.0 deg(C=8, EtOH) |
Properties (reference)
| Melting Point | 75 °C |
| Specific Rotation | 4° (C=8,EtOH) |
| Maximum Absorption Wavelength | 286 nm (EtOH) |
| Solubility in water | Insoluble |
GHS
Related Laws:
| EC Number | 224-403-8 |
| RTECS# | EJ9984000 |
Transport Information:
| HS Number | 2936280000 |
Application
α-Tocopheryl Succinate (α-TOS): an ester of Vitamin E with various biological activities
Vitamin E [T0251] is an antioxidant that protects organism from damage caused by free radicals. In contrast, α-tocopheryl succinate (α-TOS), an ester of Vitamin E, lacks antioxidative ability. Recently, α-TOS comes into focus due to its various biological activities such as induction of apoptosis and activation of protein kinase C.
References
- Inhibition of cell proliferation by α-tocopherol. Role of protein kinase C
- Induction of cancer cell apoptosis by α-tocopheryl succinate: molecular pathways and structural requirements
- Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo
- Vitamin E succinate and cancer treatment: a vitamin E prototype for selective antitumour activity (a review)
- Vitamin E analogues and immune response in cancer treatment (a review)
PubMed Literature
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