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CAS RN: 321-64-2 | Product Number: T3994
Tacrine
×
Purity: >98.0%(T)(HPLC)
Synonyms:
- 1,2,3,4-Tetrahydroacridin-9-amine
- 1,2,3,4-Tetrahydro-9-acridinamine
- 9-Amino-1,2,3,4-tetrahydroacridine
- THA
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
Shipping Information
|
|---|---|---|---|---|---|
| 250MG |
€44.00
|
1 | 15 |
|
|
| 1G |
€154.00
|
1 | 2 |
|
* Stock available in Belgium: Shipment on the same day
* Stock available in Japan: Please check the Shipping Simulation for estimated shipments. (excludes regulated items and dry ice shipments)
| Product Number | T3994 |
Purity / Analysis Method 
|
>98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__1__3H__1__4N__2 = 198.27 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature
|
Room Temperature (Recommended in a cool and dark place, <15°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive |
| Packaging and Container
|
1G-Glass Bottle with Plastic Insert (View image), 250MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 321-64-2 |
| Reaxys Registry Number | 147610 |
| PubChem Substance ID | 468593059 |
| MDL Number | MFCD00046923 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| Melting point | 181.0 to 185.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 183 °C |
| Maximum Absorption Wavelength | 325 nm (EtOH) |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H301 : Toxic if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 206-291-2 |
| RTECS# | AR9532100 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | III |
| HS Number | 2933998090 |
Application
Mitochondria research
References
- Tacrine Inhibits Topoisomerases and DNA Synthesis to Cause Mitochondrial DNA Depletion and Apoptosis in Mouse Liver
- Uncoupling of Rat and Human Mitochondria: A Possible Explanation for Tacrine-Induced Liver Dysfunction
Application
Tacrine: A Reversible Cholinesterase Inhibitor
Tacrine is a reversible cholinesterase inhibitor, and the first approved agent for the treatment of Alzheimer's disease.1) The mechanism of action of tacrine is thought to inhibit the metabolism of acetylcholine and therefore extending its activity and raising levels in the cerebral cortex.2,3) However, since tacrine shows various side effects and toxicity, the development of the next generation inhibitors such as donepezil [D4099 (HCl salt)] is underway.3,4) (The product is for research purpose only.)
References
- 1) Tacrine
- 2) Tacrine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in Alzheimer's disease
- 3) A review on cholinesterase inhibitors for Alzheimer's disease
- 4) A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease
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